Effect of the Nature of Substituents in the Oxyacridine Ligands on the Luminescence Properties and Cytotoxicity of the Zinc Complexes

• Published in: Russian journal of coordination chemistry Vol. 47; no. 11; pp. 730 - 740
• Main Authors: Balashova, T. V., Polyakova, S. K., Kukinov, A. A., Rumyantsev, R. V., Fukin, G. K., Ilichev, V. A., Gracheva, Yu. A., Antonenko, T. A., Milaeva, E. R., Bochkarev, M. N.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.11.2021; Springer Nature B.V
• Subjects: Chemistry; Chemistry and Materials Science; Coordination compounds; Electroluminescence; Inorganic Chemistry; Ligands; Luminescence; Optical properties; Photoexcitation; Physical Chemistry; Structural analysis; Synthesis; Toxicity; Zinc compounds; photoluminescence; substituents; electroluminescence; 1,3-di; X-ray structure analysis; butylacridin-4-ol; zinc; cytotoxicity
• ISSN: 1070-3284; 1608-3318
• DOI: 10.1134/S1070328421100018

Zinc complexes with oxyacridine ligands (Zn(Acr) 2 and [Zn(Acr)Et] 2 ) are synthesized, and their structures are determined by X-ray structure analysis (CIF files CCDC nos. 2063229 and 2063230, respectively). The complexes exhibit a medium-intensity emission with maxima at 700 and 630 nm upon photoexcitation (λ = 405 nm). Both compounds also manifest weak electroluminescence properties. The complexes with methyl substituents in the ligands are the most luminescence-active of the whole series of the synthesized zinc compounds with the oxyacridine ligands Zn(Acr R ) 2 and [Zn(Acr R )Et] 2 (R = Me, Br, H). The results of the MTT assay show a moderate cytotoxic activity of the synthesized compounds.