Age-related variations in relative abundance of alternative spliced D2 receptor mRNAs in brain areas of two rat strains

Age-related reduction in the steady-state levels of messenger RNA for D2(415) and D2(444), the alternatively spliced form of dopamine D2 receptors, was observed in different rat brain areas using the sensitive reverse transcription (RT)-polymerase chain reaction (PCR) technique. In both Sprague-Dawl...

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Bibliographic Details
Published inBrain research. Molecular brain research. Vol. 12; no. 4; p. 357
Main Authors Della Vedova, F, Fumagalli, F, Sacchetti, G, Racagni, G, Brunello, N
Format Journal Article
LanguageEnglish
Published Netherlands 01.02.1992
Subjects
Aging
Animals
Base Sequence
Brain - growth & development
Brain - physiology
Exons
Male
Molecular Sequence Data
Oligodeoxyribonucleotides
Rats
Rats, Inbred Strains
Receptors, Dopamine - genetics
Receptors, Dopamine D2
RNA - genetics
RNA - isolation & purification
RNA Splicing
RNA, Messenger - genetics
RNA, Messenger - metabolism
Species Specificity
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Summary:Age-related reduction in the steady-state levels of messenger RNA for D2(415) and D2(444), the alternatively spliced form of dopamine D2 receptors, was observed in different rat brain areas using the sensitive reverse transcription (RT)-polymerase chain reaction (PCR) technique. In both Sprague-Dawley and Wistar aged rats, the decrease was more pronounced in the D2(444) isoform mRNA thus leading to a changed ratio in striatum as well as in the hippocampus.
ISSN:0169-328X
DOI:10.1016/0169-328X(92)90140-7