5-HT1A receptors activate a potassium conductance in rat ventromedial hypothalamic neurones

The extracellularly recorded firing rate of rat ventromedial hypothalamic neurones in vitro was inhibited by 5-hydroxytryptamine (5-HT), 5-carboxamidotryptamine (5-CT), 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and buspirone, 2-methyl-5-HT was relatively ineffective. At 1 microM, spiperone...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 210; no. 2; p. 209
Main Author Newberry, N R
Format Journal Article
LanguageEnglish
Published Netherlands 14.01.1992
Subjects
Animals
In Vitro Techniques
Neural Conduction - drug effects
Neural Conduction - physiology
Neurons - drug effects
Neurons - physiology
Potassium Channels - drug effects
Potassium Channels - physiology
Rats
Receptors, Serotonin - drug effects
Receptors, Serotonin - physiology
Ventromedial Hypothalamic Nucleus - cytology
Ventromedial Hypothalamic Nucleus - drug effects
Ventromedial Hypothalamic Nucleus - physiology
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Summary:The extracellularly recorded firing rate of rat ventromedial hypothalamic neurones in vitro was inhibited by 5-hydroxytryptamine (5-HT), 5-carboxamidotryptamine (5-CT), 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and buspirone, 2-methyl-5-HT was relatively ineffective. At 1 microM, spiperone and cyanopindolol antagonised the 5-CT induced inhibition, MDL 72222 (10 microM) and ketanserin (1 microM) did not. Intracellular recordings with voltage-clamp revealed that 5-HT and 5-CT evoked a tetrodotoxin-resistant outward current with a reversal potential of ca. -100 mV. 5-HT1A receptors likely activate a potassium conductance on these neurones.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(92)90673-R