Micellar nanocontainers based on cationic surfactants with a pyrrolidinium head group for increasing drug bioavailability
A homologous series of cationic surfactants with a pyrrolidinium head group containing a hydroxyethyl moiety was studied for the solubilization of nonsteroidal anti-inflammatory drugs, indomethacin and meloxicam, and the antioxidant quercetin. For indomethacin, the solubilization capacity linearly i...
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| Published in | Russian chemical bulletin Vol. 70; no. 7; pp. 1341 - 1348 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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New York
Springer US
01.07.2021
Springer Nature B.V |
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| Abstract | A homologous series of cationic surfactants with a pyrrolidinium head group containing a hydroxyethyl moiety was studied for the solubilization of nonsteroidal anti-inflammatory drugs, indomethacin and meloxicam, and the antioxidant quercetin. For indomethacin, the solubilization capacity linearly increases with increasing number of carbon atoms in the alkyl chain. In the case of quercetin and meloxicam, the solubilization capacity passes through a maximum for the hexadecyl derivative. The possibility of solubilization by premicellar surfactant aggregates was shown for indomethacin and meloxicam. |
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| AbstractList | A homologous series of cationic surfactants with a pyrrolidinium head group containing a hydroxyethyl moiety was studied for the solubilization of nonsteroidal anti-inflammatory drugs, indomethacin and meloxicam, and the antioxidant quercetin. For indomethacin, the solubilization capacity linearly increases with increasing number of carbon atoms in the alkyl chain. In the case of quercetin and meloxicam, the solubilization capacity passes through a maximum for the hexadecyl derivative. The possibility of solubilization by premicellar surfactant aggregates was shown for indomethacin and meloxicam. |
| Author | Lukashenko, S. S. Kuznetsova, D. A. Valeeva, F. G. Vasileva, L. A. Vasilieva, E. A. Gaynanova, G. A. Zakharova, L. Ya |
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| Keywords | quercetin meloxicam pyrrolidinium surfactants solubilization indomethacin |
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| Title | Micellar nanocontainers based on cationic surfactants with a pyrrolidinium head group for increasing drug bioavailability |
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