Micellar nanocontainers based on cationic surfactants with a pyrrolidinium head group for increasing drug bioavailability

A homologous series of cationic surfactants with a pyrrolidinium head group containing a hydroxyethyl moiety was studied for the solubilization of nonsteroidal anti-inflammatory drugs, indomethacin and meloxicam, and the antioxidant quercetin. For indomethacin, the solubilization capacity linearly i...

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Bibliographic Details
Published inRussian chemical bulletin Vol. 70; no. 7; pp. 1341 - 1348
Main Authors Vasileva, L. A., Kuznetsova, D. A., Valeeva, F. G., Vasilieva, E. A., Lukashenko, S. S., Gaynanova, G. A., Zakharova, L. Ya
Format Journal Article
LanguageEnglish
Published New York Springer US 01.07.2021
Springer Nature B.V
Subjects
Antioxidants
Atomic properties
Bioavailability
Cations
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Homology
Inorganic Chemistry
Organic Chemistry
Solubilization
Surfactants
quercetin
meloxicam
pyrrolidinium surfactants
solubilization
indomethacin
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Summary:A homologous series of cationic surfactants with a pyrrolidinium head group containing a hydroxyethyl moiety was studied for the solubilization of nonsteroidal anti-inflammatory drugs, indomethacin and meloxicam, and the antioxidant quercetin. For indomethacin, the solubilization capacity linearly increases with increasing number of carbon atoms in the alkyl chain. In the case of quercetin and meloxicam, the solubilization capacity passes through a maximum for the hexadecyl derivative. The possibility of solubilization by premicellar surfactant aggregates was shown for indomethacin and meloxicam.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-021-3221-4