Severe rhabdomyolysis caused by Plasmodium vivax malaria in the Brazilian Amazon

Severe rhabdomyolysis (creatine phosphokinase = 29,400 U/L) developed in a 16-year-old boy from Manaus, Brazil, after he started treatment with chloroquine for infection with Plasmodium vivax. Treatment led to myoglobinuria and acute renal failure. After hemodialysis, the patient improved and a musc...

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Published inThe American journal of tropical medicine and hygiene Vol. 83; no. 2; pp. 271 - 273
Main Authors Siqueira, André M, Alexandre, Márcia A A, Mourão, Maria P G, Santos, Valquir S, Nagahashi-Marie, Suely K, Alecrim, Maria G C, Lacerda, Marcus V G
Format Journal Article
LanguageEnglish
Published United States The American Society of Tropical Medicine and Hygiene 05.08.2010
SeriesCase Report
Subjects
Adolescent
Animals
Brazil
Humans
Malaria, Vivax - complications
Malaria, Vivax - drug therapy
Male
Plasmodium vivax
Rhabdomyolysis - complications
Rhabdomyolysis - parasitology
Brazil
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Summary:Severe rhabdomyolysis (creatine phosphokinase = 29,400 U/L) developed in a 16-year-old boy from Manaus, Brazil, after he started treatment with chloroquine for infection with Plasmodium vivax. Treatment led to myoglobinuria and acute renal failure. After hemodialysis, the patient improved and a muscle biopsy specimen showed no myophosphorylase or deaminase deficiency. This case of rhabdomyolysis associated with P. vivax infection showed no comorbidities. The pathogenesis is still unclear. Although rhabdomyolysis is generally reported as a complication of Plasmodium falciparum malaria, leading to metabolic and renal complications,1 it has been reported in a patient with P. vivax infection with myoadenylate deaminase deficiency.2 We report a case in a patient without typical muscle enzyme deficiencies in which severe rhabdomyolysis developed while the patients was being treated with chloroquine for a confirmed P. vivax infection.
Bibliography:ObjectType-Case Study-2
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ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.2010.10-0027