Study of succinic anhydride amidation by 2-aminothiazol

Abstract The reaction between succinic anhydride and 2-aminothiazole was carried out in polar organic solvents (acetone, 1,4-dioxane, isopropanol) and in a mechanochemical reactor. By of X-ray phase analysis, IR, 1 H, 13 C NMR spectroscopy it was found that in both techniques of carrying out the rea...

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Published inJournal of physics. Conference series Vol. 2052; no. 1; pp. 12047 - 12053
Main Authors Tyurina, T G, Kryuk, T V, Kudryavtseva, T A, Semenova, R G, Romanenko, N A, Volkova, G K
Format Journal Article
LanguageEnglish
Published IOP Publishing 01.11.2021
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Summary:Abstract The reaction between succinic anhydride and 2-aminothiazole was carried out in polar organic solvents (acetone, 1,4-dioxane, isopropanol) and in a mechanochemical reactor. By of X-ray phase analysis, IR, 1 H, 13 C NMR spectroscopy it was found that in both techniques of carrying out the reaction, the only product was succinamide. It was shown that the process efficiency in the mechanochemical reaction conditions is higher in comparison with the traditional solution’s synthesis. The solid-phase interaction development was proceeded during 45 days after load removed, it was especially intense in the first 10 days.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/2052/1/012047