Highlight of 2023: Advances in pediatric immunology

In this article for the Highlights of 2023 Series, significant advancements in pediatric immunology are discussed, focusing on new diagnostic and therapeutic approaches. Key studies include the integration of genomic and proteomic profiling for better diagnosis of inborn errors of immunity, the impa...

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Bibliographic Details
Published inImmunology and cell biology Vol. 102; no. 6; p. 460
Main Author Van Nieuwenhove, Erika
Format Journal Article
LanguageEnglish
Published United States 01.07.2024
Subjects
Allergy and Immunology
Autoimmune Diseases - immunology
Autoimmune Diseases - therapy
Child
Humans
Pediatrics
Precision Medicine
Proteomics - methods
immunological disorders
primary immunodeficiency disorders
translational immunology
Autoimmune diseases
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Summary:In this article for the Highlights of 2023 Series, significant advancements in pediatric immunology are discussed, focusing on new diagnostic and therapeutic approaches. Key studies include the integration of genomic and proteomic profiling for better diagnosis of inborn errors of immunity, the impact of nongenetic factors such as autoantibodies on immune responses, the promising use of Janus kinase inhibitors and chimeric antigen receptor-T cell therapy for treating immune deficiencies and autoimmune diseases and the potential for a curative approach using prime editing. These developments mark a shift toward personalized and precision medicine in pediatric immunology.
ISSN:1440-1711
DOI:10.1111/imcb.12790