LNA stereoisomers: xylo-LNA (beta-D-xylo configured locked nucleic acid) and alpha-L-LNA (alpha-L-ribo configured locked nucleic acid)

Synthesis of xylo-LNA containing one 2'-O,4'-C-methylene-beta-D-xylofuranosyl thymine nucleotide monomer and alpha-L-LNAs containing one or four 2'-O,4'-C-methylene-alpha-L-ribofuranosyl thymine nucleotide monomer(s) has been accomplished using phosphoramidite chemistry with pyri...

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 15; pp. 1395 - 1396
Main Authors Rajwanshi, VK, Hakansson, AE, Dahl, BM, Wengel, J
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.1999
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
RECOGNITION
SOLID-PHASE SYNTHESIS
ANALOGS
BUILDING-BLOCKS
DNA
OLIGONUCLEOTIDE SYNTHESIS
BACKBONE
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Summary:Synthesis of xylo-LNA containing one 2'-O,4'-C-methylene-beta-D-xylofuranosyl thymine nucleotide monomer and alpha-L-LNAs containing one or four 2'-O,4'-C-methylene-alpha-L-ribofuranosyl thymine nucleotide monomer(s) has been accomplished using phosphoramidite chemistry with pyridine hydrochloride as activator; oligothymidylate alpha-L-LNA displays strongly enhanced affinity towards complementary RNA.
ISSN:1359-7345
1364-548X
DOI:10.1039/a903189h