Novel glucomannan-like polysaccharide from Lycium barbarum L. ameliorates renal fibrosis via blocking macrophage-to-myofibroblasts transition
The macrophage to myofibroblasts transition (MMT) has been reported as a newly key target in renal fibrosis. Lycium barbarum L. is a traditional Chinese medicine for improving renal function, in which its polysaccharides (LBPs) are the mainly active components. However, whether the role of LBPs in t...
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| Published in | International journal of biological macromolecules Vol. 278; no. Pt 2; p. 134491 |
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| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.10.2024
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The macrophage to myofibroblasts transition (MMT) has been reported as a newly key target in renal fibrosis. Lycium barbarum L. is a traditional Chinese medicine for improving renal function, in which its polysaccharides (LBPs) are the mainly active components. However, whether the role of LBPs in treating renal fibrosis is related to MMT process remain unclear. The purpose of this study was to explore the relationship between the regulating effect on MMT process and the anti-fibrotic effect of LBPs. Initially, small molecular weight LBPs fractions (LBP-S) were firstly isolated via Sephadex G-100 column. Then, the potent inhibitory effect of LBP-S on MMT process was revealed on bone marrow-derived macrophages (BMDM) model induced by TGF-β. Subsequently, the chemical structure of LBP-S was elucidated through monosaccharide, methylation and NMR spectrum analysis. In vivo biodistribution characteristics studies demonstrated that LBP-S exhibited effectively accumulation in kidney via intraperitoneal administration. Finally, LBP-S showed a satisfactory anti-renal fibrotic effect on unilateral ureteral obstruction operation (UUO) mice, which was significantly reduced following macrophage depletion. Overall, our findings indicated that LPB-S could alleviate renal fibrosis through regulating MMT process and providing new candidate agents for chronic kidney disease (CKD) related fibrosis treatment.
Diagram showing the extraction and isolation, structural characterization and MMT effectiveness of Lycium barbarum L. polysaccharides. [Display omitted] |
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| AbstractList | The macrophage to myofibroblasts transition (MMT) has been reported as a newly key target in renal fibrosis. Lycium barbarum L. is a traditional Chinese medicine for improving renal function, in which its polysaccharides (LBPs) are the mainly active components. However, whether the role of LBPs in treating renal fibrosis is related to MMT process remain unclear. The purpose of this study was to explore the relationship between the regulating effect on MMT process and the anti-fibrotic effect of LBPs. Initially, small molecular weight LBPs fractions (LBP-S) were firstly isolated via Sephadex G-100 column. Then, the potent inhibitory effect of LBP-S on MMT process was revealed on bone marrow-derived macrophages (BMDM) model induced by TGF-β. Subsequently, the chemical structure of LBP-S was elucidated through monosaccharide, methylation and NMR spectrum analysis. In vivo biodistribution characteristics studies demonstrated that LBP-S exhibited effectively accumulation in kidney via intraperitoneal administration. Finally, LBP-S showed a satisfactory anti-renal fibrotic effect on unilateral ureteral obstruction operation (UUO) mice, which was significantly reduced following macrophage depletion. Overall, our findings indicated that LPB-S could alleviate renal fibrosis through regulating MMT process and providing new candidate agents for chronic kidney disease (CKD) related fibrosis treatment. The macrophage to myofibroblasts transition (MMT) has been reported as a newly key target in renal fibrosis. Lycium barbarum L. is a traditional Chinese medicine for improving renal function, in which its polysaccharides (LBPs) are the mainly active components. However, whether the role of LBPs in treating renal fibrosis is related to MMT process remain unclear. The purpose of this study was to explore the relationship between the regulating effect on MMT process and the anti-fibrotic effect of LBPs. Initially, small molecular weight LBPs fractions (LBP-S) were firstly isolated via Sephadex G-100 column. Then, the potent inhibitory effect of LBP-S on MMT process was revealed on bone marrow-derived macrophages (BMDM) model induced by TGF-β. Subsequently, the chemical structure of LBP-S was elucidated through monosaccharide, methylation and NMR spectrum analysis. In vivo biodistribution characteristics studies demonstrated that LBP-S exhibited effectively accumulation in kidney via intraperitoneal administration. Finally, LBP-S showed a satisfactory anti-renal fibrotic effect on unilateral ureteral obstruction operation (UUO) mice, which was significantly reduced following macrophage depletion. Overall, our findings indicated that LPB-S could alleviate renal fibrosis through regulating MMT process and providing new candidate agents for chronic kidney disease (CKD) related fibrosis treatment.The macrophage to myofibroblasts transition (MMT) has been reported as a newly key target in renal fibrosis. Lycium barbarum L. is a traditional Chinese medicine for improving renal function, in which its polysaccharides (LBPs) are the mainly active components. However, whether the role of LBPs in treating renal fibrosis is related to MMT process remain unclear. The purpose of this study was to explore the relationship between the regulating effect on MMT process and the anti-fibrotic effect of LBPs. Initially, small molecular weight LBPs fractions (LBP-S) were firstly isolated via Sephadex G-100 column. Then, the potent inhibitory effect of LBP-S on MMT process was revealed on bone marrow-derived macrophages (BMDM) model induced by TGF-β. Subsequently, the chemical structure of LBP-S was elucidated through monosaccharide, methylation and NMR spectrum analysis. In vivo biodistribution characteristics studies demonstrated that LBP-S exhibited effectively accumulation in kidney via intraperitoneal administration. Finally, LBP-S showed a satisfactory anti-renal fibrotic effect on unilateral ureteral obstruction operation (UUO) mice, which was significantly reduced following macrophage depletion. Overall, our findings indicated that LPB-S could alleviate renal fibrosis through regulating MMT process and providing new candidate agents for chronic kidney disease (CKD) related fibrosis treatment. The macrophage to myofibroblasts transition (MMT) has been reported as a newly key target in renal fibrosis. Lycium barbarum L. is a traditional Chinese medicine for improving renal function, in which its polysaccharides (LBPs) are the mainly active components. However, whether the role of LBPs in treating renal fibrosis is related to MMT process remain unclear. The purpose of this study was to explore the relationship between the regulating effect on MMT process and the anti-fibrotic effect of LBPs. Initially, small molecular weight LBPs fractions (LBP-S) were firstly isolated via Sephadex G-100 column. Then, the potent inhibitory effect of LBP-S on MMT process was revealed on bone marrow-derived macrophages (BMDM) model induced by TGF-β. Subsequently, the chemical structure of LBP-S was elucidated through monosaccharide, methylation and NMR spectrum analysis. In vivo biodistribution characteristics studies demonstrated that LBP-S exhibited effectively accumulation in kidney via intraperitoneal administration. Finally, LBP-S showed a satisfactory anti-renal fibrotic effect on unilateral ureteral obstruction operation (UUO) mice, which was significantly reduced following macrophage depletion. Overall, our findings indicated that LPB-S could alleviate renal fibrosis through regulating MMT process and providing new candidate agents for chronic kidney disease (CKD) related fibrosis treatment. Diagram showing the extraction and isolation, structural characterization and MMT effectiveness of Lycium barbarum L. polysaccharides. [Display omitted] |
| ArticleNumber | 134491 |
| Author | Gong, He-xin Fan, Yi-kai Wu, Jin-jia Dong, Zheng-qi Wu, Ze Li, Nan Zhang, Zi-qian Liu, Tian Jin, Bing Zhang, Yun Dong, Xi Zhao, Chen-jing Han, Miao-miao Xiong, Ying-xia |
| Author_xml | – sequence: 1 givenname: Tian surname: Liu fullname: Liu, Tian organization: IMPLAD, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine from Ministry of Education, CAMS, Beijing 100193, China – sequence: 2 givenname: Yun surname: Zhang fullname: Zhang, Yun organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China – sequence: 3 givenname: Ze surname: Wu fullname: Wu, Ze organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China – sequence: 4 givenname: Chen-jing surname: Zhao fullname: Zhao, Chen-jing organization: IMPLAD, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine from Ministry of Education, CAMS, Beijing 100193, China – sequence: 5 givenname: Xi surname: Dong fullname: Dong, Xi organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China – sequence: 6 givenname: He-xin surname: Gong fullname: Gong, He-xin organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China – sequence: 7 givenname: Bing surname: Jin fullname: Jin, Bing organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China – sequence: 8 givenname: Miao-miao surname: Han fullname: Han, Miao-miao organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China – sequence: 9 givenname: Jin-jia surname: Wu fullname: Wu, Jin-jia organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China – sequence: 10 givenname: Yi-kai surname: Fan fullname: Fan, Yi-kai organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China – sequence: 11 givenname: Nan surname: Li fullname: Li, Nan organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China – sequence: 12 givenname: Ying-xia surname: Xiong fullname: Xiong, Ying-xia organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China – sequence: 13 givenname: Zi-qian surname: Zhang fullname: Zhang, Zi-qian organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China – sequence: 14 givenname: Zheng-qi surname: Dong fullname: Dong, Zheng-qi email: zqdong@implad.ac.cn organization: Institute of Medicinal Plant Development (IMPLAD), State Key Laboratory of Quality Ensurance and Sustainable Use of Dao-Di herbs, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS), Beijing 100193, China |
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| Cites_doi | 10.1016/j.foodchem.2014.08.024 10.1016/j.heliyon.2023.e21882 10.1016/j.biopha.2019.109020 10.1016/j.foodchem.2014.02.171 10.3389/fphar.2024.1367747 10.1016/j.ijbiomac.2017.09.047 10.1038/nm.3218 10.7150/ijbs.39024 10.2147/JIR.S413374 10.1159/000373932 10.3390/ph16060895 10.1016/j.carbpol.2021.118383 10.1007/s10570-023-05442-y 10.1016/j.carbpol.2009.11.038 10.1002/jcp.29512 10.1016/j.carbpol.2019.03.099 10.1016/j.ijbiomac.2022.01.101 10.1016/j.carbpol.2021.118772 10.1016/j.carbpol.2023.121709 10.1016/j.fshw.2020.05.003 10.1021/jf302619c 10.1016/j.carbpol.2016.03.087 10.1016/j.carbpol.2019.115362 10.1016/j.ijbiomac.2022.06.078 10.1016/j.ymthe.2022.06.019 10.1016/j.lwt.2014.04.020 10.3390/pharmaceutics14122677 10.1016/j.carbpol.2021.118939 10.1016/j.tifs.2018.07.016 10.1016/j.ijbiomac.2020.04.196 10.1681/ASN.2016050573 10.1016/j.ijbiomac.2023.125452 10.1016/j.carbpol.2016.12.041 10.1016/j.biopha.2023.116039 10.1016/j.pharmthera.2021.107921 10.1016/j.lfs.2016.05.045 10.1016/j.carbpol.2010.01.038 10.1142/S0192415X20500858 10.1016/j.addr.2017.12.019 10.1126/scisignal.aaz2597 10.1016/j.ijbiomac.2015.10.069 10.1111/cpr.12547 10.1016/j.carbpol.2023.121423 10.1016/j.biopha.2021.111386 10.1155/2020/1903056 10.1016/j.foodhyd.2014.05.015 10.1021/acsnano.3c05998 10.3389/fimmu.2022.948658 10.1016/j.ab.2020.113624 10.1016/j.ijbiomac.2022.09.137 10.1016/j.ijbiomac.2021.02.191 10.3389/fpls.2015.00628 10.1016/j.intimp.2021.107907 10.1021/acs.molpharmaceut.1c00827 |
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| Keywords | Macrophage to myofibroblasts transition Renal fibrosis Lycium barbarum L Polysaccharide Chemical structure |
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| References | Ma, Wei, Qi, Pu, Dong, Xu, Zhou, Zhu, Chen, Wang, Su (bb0330) 2021; 13 Wu, Guo, Lin, Lam, Zhao, Lin, Qin (bb0195) 2018; 79 Luo, Wang, Hu, Wang, Jiang, Zhang, Liu, Guo, Luo, Zhu, Xie, Li, You, Yang (bb0295) 2023; 17 Wei, Xu, Yan (bb0005) 2022; 13 Lin, Wu, Wang, Tang, Sun, Xu, Jiang, Chu, Chen, Li, Su, Zhang, Wu, Yang, Wu, Liang (bb0310) 2019; 52 Rjeibi, Zaabi, Jouida (bb0140) 2020; 2020 Zhang, Zhang, Liu, Wang, Wang, Liu, Yang, Zhong (bb0260) 2022; 201 Li, Xiong, Ye, Jin, Wu, Han, Liu, Fan, Li, Liu, Zhang, Sun, Zhang, Dong (bb0125) 2023; 16 Sheng, Wen, Yang (bb0245) 2022; 278 Qiang, Hao, Yang, Han, Chang, Xian, Xiong, Gao, Liang, Shimosawa, Xu (bb0055) 2022; 13 Huang, Jing, Wu, Ding (bb0085) 2022; 276 Xia, Zhao (bb0210) 2016; 35 Sun, Ma, Zuo, Liu, Xia, Wang, Guo, Han (bb0115) 2023; 84 Hu, Zhao, Li, Zhang, Pan, Lu, Li, Bao (bb0270) 2023; 245 Bai, Wang, Yin, Gao, Na, Sun, Wang, Zhang, Zhao (bb0155) 2020; 16 Xu, Jiang, Xie, Xu, Zhou, Lu, Wang, Dong, Zuo (bb0315) 2023; 9 Chunhui (bb0180) 2001 C.P. Commission (bb0090) 2020 Nastase, Zeng-Brouwers, Wygrecka, Schaefer (bb0040) 2018; 129 Xiao, Xu, Tang, Rui, Zhang, Chen, Dong, Li (bb0290) 2021; 3 Sun, Zuo, Liu, Guo, Wang, Dong, Han (bb0110) 2022; 14 Chen, Tang, Zhong, Wei, Huang, Tang, Xu, Lan (bb0300) 2022; 30 Ma, Ai, Xiao, Wang, Shi, Bai, Zhu, Ma (bb0065) 2024; 15 Shi, Zhou, Zheng, Jing, Zhang, Yuan, Zhang, Li, Huang, Xie, Xiong (bb0080) 2023; 253 Xiao, Li, Tian, Zhou, Xu, Feng, Rui, Fan, Zhang, Chen, Dong, Li (bb0285) 2020; 157 Rajendar, Mulagalapati, Reddy, Patri, Karthik, Matur (bb0130) 2020; 595 Yang, Ren, Zhou, Li, Ren, Ji, Mao (bb0255) 2024; 324 Lovisa, Fletcher-Sananikone, Sugimoto, Hensel, Lahiri, Hertig, Taduri, Lawson, Dewar, Revuelta, Kato, Wu, Bassett, Putluri, Zeisberg, Zeisberg, LeBleu, Kalluri (bb0025) 2020; 13 Liu, Jiang, Liang, Xiao, Lai, Nie, Yu, Gao, Wen (bb0035) 2021; 98 Zhang, Du, Poon, He, Wong, Wang, Zhang (bb0075) 2023; 302 Sindhu, Goyal, Das, Neha, Choden (bb0225) 2021; 2 Feng, Wang, Ning, Chen, Liu (bb0030) 2021; 139 Lu, Zhao, Zhang, Qi, Yang, Gu (bb0105) 2019; 116 Zhang, Yu, Dong, Yu, Luo, Zha (bb0060) 2021; 24 Ahmad, Ahmad, Hasan, Alsayegh, Hakami, Bantun, Tasneem, Alamie, Babalghith, Aldairi, Kambal, Elbendary (bb0070) 2024; 268 Yuan, Wang, Jiang, Prasad, Yang, Qu, Wang, Jia, Mo, Yang (bb0185) 2016; 82 Wang, Wang, Yang, Lin, Liu, Li, Zhang, Guo (bb0265) 2021; 179 Song, Zhang, Tang, Luo, Xiong, Liu, Hu, Chen, Jia, Yan, Tang, Huang (bb0010) 2024; 170 Pan, Liu, Jiang, Zheng (bb0325) 2015; 35 Xie, Ge, Li, Yang, Pan, Zha, Li, Duan, Luo (bb0305) 2018; 107 Zhang, Li, Zhang, Liao, Li (bb0050) 2023; 16 Liu, Kamilijiang, Abuduwaili, Zang, Abudukelimu, Liu, Yili, Aisa (bb0135) 2022; 222 Wang, Jiang, Pan, Huang, Wang, Huang, K.F. To, Nikolic-Paterson, Lan, Chen (bb0015) 2017; 28 Li, Xu, Wen, Yang, Li, Fan (bb0020) 2020; 235 Zhu, Jinggang, ChangSheng, Haiping, Ning, Caijiao (bb0220) 2010; 80 Zhou, Li, Sun, Liu, Zhu, Yi, Li, Hu, Wang (bb0275) 2024; 328 Sun, Shi, Zuo, Zhang, Liu, Sun, Wang (bb0320) 2022; 19 Peng, Song, Lv, Wang, Huang, Du (bb0205) 2012; 60 Chen, Zhao, Zhang, Yang, Yue, Tang, Wei (bb0160) 2020; 227 Zhang, Liu, Dou, Wu, Zheng, Pan, Zhou, Wang (bb0150) 2021; 270 Li, Wang, Zhu, Chen, Zhang, Yu, Mao, Zhao, Feng, Yang, Wu (bb0280) 2017; 161 Smith-Moritz, Hao, Fernández-Niño, Fangel, Verhertbruggen, Holman, Willats, Ronald, Scheller, Heazlewood, Vega-Sánchez (bb0235) 2015; 6 Feng, Guo, Mai, Liu, Xia, Zhu, Zhang, Ma, Fu (bb0045) 2020; 48 Wang, Liu, Sun, Mou, Wang, Zhang, Huang (bb0190) 2014; 159 Bi, Zhao, Jin, Chen, Fan, Qian (bb0145) 2022; 215 Liu, Liu, Zhu, Yu, Lu, Pan, Yao, Gao (bb0165) 2016; 147 Zhao, Li, Yan, Liu, Guo, Chen, Luo (bb0100) 2016; 157 Zhang, Wang, Liu, Tang, Zhang, Zhang (bb0175) 2014; 58 Chen, Zhang, Huo, Cao, Li, Liang, Li, Li (bb0240) 2019; 215 Pękala, Szymańska-Chargot, Zdunek (bb0230) 2023; 30 Wu, Chen, Qiao, Su, Liu (bb0250) 2021; 10 Zou, Zhang, Yao, Niu, Gao (bb0215) 2010; 80 LeBleu, Taduri, O’Connell, Teng, Cooke, Woda, Sugimoto, Kalluri (bb0120) 2013; 19 Sun, Sun, Guo, Hu, Gong, Huang, Cao, Wang (bb0170) 2015; 170 Xiao, Deng, Zhou, Zhang (bb0095) 2022; 229 Lin, Wu, Xie, Zhao, Li (bb0200) 2015; 43 Zhang (10.1016/j.ijbiomac.2024.134491_bb0050) 2023; 16 Yang (10.1016/j.ijbiomac.2024.134491_bb0255) 2024; 324 Ahmad (10.1016/j.ijbiomac.2024.134491_bb0070) 2024; 268 Sun (10.1016/j.ijbiomac.2024.134491_bb0115) 2023; 84 Bi (10.1016/j.ijbiomac.2024.134491_bb0145) 2022; 215 Chunhui (10.1016/j.ijbiomac.2024.134491_bb0180) 2001 Chen (10.1016/j.ijbiomac.2024.134491_bb0300) 2022; 30 Huang (10.1016/j.ijbiomac.2024.134491_bb0085) 2022; 276 Liu (10.1016/j.ijbiomac.2024.134491_bb0135) 2022; 222 Sun (10.1016/j.ijbiomac.2024.134491_bb0320) 2022; 19 Nastase (10.1016/j.ijbiomac.2024.134491_bb0040) 2018; 129 Xiao (10.1016/j.ijbiomac.2024.134491_bb0095) 2022; 229 Liu (10.1016/j.ijbiomac.2024.134491_bb0035) 2021; 98 Zhao (10.1016/j.ijbiomac.2024.134491_bb0100) 2016; 157 Song (10.1016/j.ijbiomac.2024.134491_bb0010) 2024; 170 Peng (10.1016/j.ijbiomac.2024.134491_bb0205) 2012; 60 Pękala (10.1016/j.ijbiomac.2024.134491_bb0230) 2023; 30 Smith-Moritz (10.1016/j.ijbiomac.2024.134491_bb0235) 2015; 6 Qiang (10.1016/j.ijbiomac.2024.134491_bb0055) 2022; 13 Zhang (10.1016/j.ijbiomac.2024.134491_bb0150) 2021; 270 C.P. Commission (10.1016/j.ijbiomac.2024.134491_bb0090) 2020 Zhang (10.1016/j.ijbiomac.2024.134491_bb0060) 2021; 24 Rjeibi (10.1016/j.ijbiomac.2024.134491_bb0140) 2020; 2020 Feng (10.1016/j.ijbiomac.2024.134491_bb0030) 2021; 139 Lin (10.1016/j.ijbiomac.2024.134491_bb0310) 2019; 52 Sun (10.1016/j.ijbiomac.2024.134491_bb0110) 2022; 14 Xia (10.1016/j.ijbiomac.2024.134491_bb0210) 2016; 35 Li (10.1016/j.ijbiomac.2024.134491_bb0020) 2020; 235 Zhang (10.1016/j.ijbiomac.2024.134491_bb0260) 2022; 201 Luo (10.1016/j.ijbiomac.2024.134491_bb0295) 2023; 17 Zhu (10.1016/j.ijbiomac.2024.134491_bb0220) 2010; 80 Wang (10.1016/j.ijbiomac.2024.134491_bb0190) 2014; 159 Wang (10.1016/j.ijbiomac.2024.134491_bb0015) 2017; 28 Chen (10.1016/j.ijbiomac.2024.134491_bb0240) 2019; 215 Sun (10.1016/j.ijbiomac.2024.134491_bb0170) 2015; 170 Wu (10.1016/j.ijbiomac.2024.134491_bb0195) 2018; 79 Lin (10.1016/j.ijbiomac.2024.134491_bb0200) 2015; 43 Ma (10.1016/j.ijbiomac.2024.134491_bb0065) 2024; 15 Sheng (10.1016/j.ijbiomac.2024.134491_bb0245) 2022; 278 Zhang (10.1016/j.ijbiomac.2024.134491_bb0075) 2023; 302 Zou (10.1016/j.ijbiomac.2024.134491_bb0215) 2010; 80 Xiao (10.1016/j.ijbiomac.2024.134491_bb0285) 2020; 157 Ma (10.1016/j.ijbiomac.2024.134491_bb0330) 2021; 13 Yuan (10.1016/j.ijbiomac.2024.134491_bb0185) 2016; 82 Lovisa (10.1016/j.ijbiomac.2024.134491_bb0025) 2020; 13 Li (10.1016/j.ijbiomac.2024.134491_bb0125) 2023; 16 Liu (10.1016/j.ijbiomac.2024.134491_bb0165) 2016; 147 Zhang (10.1016/j.ijbiomac.2024.134491_bb0175) 2014; 58 Hu (10.1016/j.ijbiomac.2024.134491_bb0270) 2023; 245 Chen (10.1016/j.ijbiomac.2024.134491_bb0160) 2020; 227 Lu (10.1016/j.ijbiomac.2024.134491_bb0105) 2019; 116 Xie (10.1016/j.ijbiomac.2024.134491_bb0305) 2018; 107 Wang (10.1016/j.ijbiomac.2024.134491_bb0265) 2021; 179 Xu (10.1016/j.ijbiomac.2024.134491_bb0315) 2023; 9 Li (10.1016/j.ijbiomac.2024.134491_bb0280) 2017; 161 Wu (10.1016/j.ijbiomac.2024.134491_bb0250) 2021; 10 Zhou (10.1016/j.ijbiomac.2024.134491_bb0275) 2024; 328 Xiao (10.1016/j.ijbiomac.2024.134491_bb0290) 2021; 3 Sindhu (10.1016/j.ijbiomac.2024.134491_bb0225) 2021; 2 Bai (10.1016/j.ijbiomac.2024.134491_bb0155) 2020; 16 LeBleu (10.1016/j.ijbiomac.2024.134491_bb0120) 2013; 19 Feng (10.1016/j.ijbiomac.2024.134491_bb0045) 2020; 48 Wei (10.1016/j.ijbiomac.2024.134491_bb0005) 2022; 13 Pan (10.1016/j.ijbiomac.2024.134491_bb0325) 2015; 35 Shi (10.1016/j.ijbiomac.2024.134491_bb0080) 2023; 253 Rajendar (10.1016/j.ijbiomac.2024.134491_bb0130) 2020; 595 |
| References_xml | – volume: 229 year: 2022 ident: bb0095 article-title: Immune activities of polysaccharides isolated from Lycium barbarum L. what do we know so far? publication-title: Pharmacol. Ther. contributor: fullname: Zhang – volume: 179 start-page: 407 year: 2021 end-page: 417 ident: bb0265 article-title: Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris publication-title: Int. J. Biol. Macromol. contributor: fullname: Guo – volume: 82 start-page: 696 year: 2016 end-page: 701 ident: bb0185 article-title: Structure identification of a polysaccharide purified from Lycium barbarium fruit publication-title: Int. J. Biol. Macromol. contributor: fullname: Yang – volume: 2 year: 2021 ident: bb0225 article-title: Immunomodulatory potential of polysaccharides derived from plants and microbes: a narrative review publication-title: Carbohydr. Polym. Technol. Appl. contributor: fullname: Choden – volume: 17 start-page: 22508 year: 2023 end-page: 22526 ident: bb0295 article-title: Precisely regulating M2 subtype macrophages for renal fibrosis resolution publication-title: ACS Nano contributor: fullname: Yang – volume: 302 year: 2023 ident: bb0075 article-title: Structural characterization and protective effect against renal fibrosis of polysaccharide from Ligustrum lucidum Ait publication-title: J. Ethnopharmacol. contributor: fullname: Zhang – volume: 80 start-page: 1161 year: 2010 end-page: 1167 ident: bb0215 article-title: Structure characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Lycium barbarum L publication-title: Carbohydr. Polym. contributor: fullname: Gao – volume: 170 start-page: 22 year: 2015 end-page: 29 ident: bb0170 article-title: Sulphation pattern analysis of chemically sulphated polysaccharide LbGp1 from Lycium barbarum by GC–MS publication-title: Food Chem. contributor: fullname: Wang – volume: 227 year: 2020 ident: bb0160 article-title: Structural characterization and antioxidant activity of a new polysaccharide from Bletilla striata fibrous roots publication-title: Carbohydr. Polym. contributor: fullname: Wei – volume: 324 year: 2024 ident: bb0255 article-title: Structural elucidation of a highly branched α-D-glucan from Huangjiu and its hepatoprotective activity via gut microbiome regulation and intestinal barrier repairment publication-title: Carbohydr. Polym. contributor: fullname: Mao – volume: 13 start-page: 1290 year: 2021 end-page: 1306 ident: bb0330 article-title: Schistosoma japonicum-derived peptide SJMHE1 promotes peripheral nerve repair through a macrophage-dependent mechanism publication-title: Am. J. Transl. Res. contributor: fullname: Su – volume: 28 start-page: 2053 year: 2017 end-page: 2067 ident: bb0015 article-title: Macrophage-to-Myofibroblast transition contributes to interstitial fibrosis in chronic renal allograft injury publication-title: J. Am. Soc. Nephrol.: JASN contributor: fullname: Chen – volume: 129 start-page: 295 year: 2018 end-page: 307 ident: bb0040 article-title: Targeting renal fibrosis: mechanisms and drug delivery systems publication-title: Adv. Drug Deliv. Rev. contributor: fullname: Schaefer – volume: 19 start-page: 3075 year: 2022 end-page: 3084 ident: bb0320 article-title: Kidney-targeted drug delivery system based on metformin-grafted chitosan for renal fibrosis therapy publication-title: Mol. Pharm. contributor: fullname: Wang – volume: 222 start-page: 154 year: 2022 end-page: 166 ident: bb0135 article-title: Isolation, structure elucidation, and biological activity of polysaccharides from Saussurea involucrata publication-title: Int. J. Biol. Macromol. contributor: fullname: Aisa – volume: 58 start-page: 594 year: 2014 end-page: 601 ident: bb0175 article-title: Effects of superfine grinding on physicochemical and antioxidant properties of Lycium barbarum polysaccharides publication-title: LWT Food Sci. Technol. contributor: fullname: Zhang – volume: 161 start-page: 42 year: 2017 end-page: 52 ident: bb0280 article-title: Structural elucidation and antioxidant activity a novel Se-polysaccharide from Se-enriched Grifola frondosa publication-title: Carbohydr. Polym. contributor: fullname: Wu – volume: 13 year: 2020 ident: bb0025 article-title: Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis publication-title: Sci. Signal. contributor: fullname: Kalluri – volume: 43 start-page: 199 year: 2015 end-page: 206 ident: bb0200 article-title: Characterization and comparison of bioactive polysaccharides from the tubers of Gymnadenia conopsea publication-title: Food Hydrocoll. contributor: fullname: Li – volume: 30 start-page: 3017 year: 2022 end-page: 3033 ident: bb0300 article-title: P2Y12 inhibitor clopidogrel inhibits renal fibrosis by blocking macrophage-to-myofibroblast transition publication-title: Mol. Ther. contributor: fullname: Lan – volume: 139 year: 2021 ident: bb0030 article-title: Small molecules against the origin and activation of myofibroblast for renal interstitial fibrosis therapy publication-title: Biomed. Pharmacother. contributor: fullname: Liu – volume: 253 year: 2023 ident: bb0080 article-title: Therapeutic mechanism exploration of polysaccharides from Dendrobium officinale on unilateral ureteral obstruction operation-induced renal fibrosis based on improving oxidative stress injury mediated by AhR/NOX4 pathway publication-title: Int. J. Biol. Macromol. contributor: fullname: Xiong – volume: 2020 start-page: 1903056 year: 2020 ident: bb0140 article-title: Characterization of polysaccharides extracted from pulps and seeds of Crataegus azarolus L. var. aronia: preliminary structure, antioxidant, antibacterial, α-amylase, and acetylcholinesterase inhibition properties publication-title: Oxid. Med. Cell. Longev. contributor: fullname: Jouida – volume: 201 start-page: 630 year: 2022 end-page: 640 ident: bb0260 article-title: A natural selenium polysaccharide from Pleurotus ostreatus: structural elucidation, anti-gastric cancer and anti-colon cancer activity in vitro publication-title: Int. J. Biol. Macromol. contributor: fullname: Zhong – volume: 52 year: 2019 ident: bb0310 article-title: QingBai decoction regulates intestinal permeability of dextran sulphate sodium-induced colitis through the modulation of notch and NF-κB signalling publication-title: Cell Prolif. contributor: fullname: Liang – volume: 24 start-page: 752 year: 2021 end-page: 759 ident: bb0060 article-title: Verbascoside alleviates renal fibrosis in unilateral ureteral obstruction rats by inhibiting macrophage infiltration publication-title: Iran. J. Basic Med. Sci. contributor: fullname: Zha – volume: 13 year: 2022 ident: bb0055 article-title: Esaxerenone inhibits the macrophage-to-myofibroblast transition through mineralocorticoid receptor/TGF-β1 pathway in mice induced with aldosterone publication-title: Front. Immunol. contributor: fullname: Xu – volume: 157 start-page: 220 year: 2020 end-page: 231 ident: bb0285 article-title: Influences of drying methods on the structural, physicochemical and antioxidant properties of exopolysaccharide from Lactobacillus helveticus MB2-1 publication-title: Int. J. Biol. Macromol. contributor: fullname: Li – volume: 80 start-page: 672 year: 2010 end-page: 676 ident: bb0220 article-title: Extraction, characterization of polysaccharides from lycium barbarum and its effect on bone gene expression in rats publication-title: Carbohydr. Polym. contributor: fullname: Caijiao – volume: 10 start-page: 63 year: 2021 end-page: 71 ident: bb0250 article-title: Purification, structural elucidation, and in vitro antitumor effects of novel polysaccharides from Bangia fuscopurpurea publication-title: Food Sci. Human Wellness contributor: fullname: Liu – volume: 14 start-page: 2677 year: 2022 ident: bb0110 article-title: Combined photothermal therapy and Lycium barbarum polysaccharide for topical administration to improve the efficacy of doxorubicin in the treatment of breast cancer publication-title: Pharmaceutics contributor: fullname: Han – volume: 15 start-page: 1367747 year: 2024 ident: bb0065 article-title: Lycium barbarum polysaccharide reverses drug resistance in oxaliplatin-resistant colon cancer cells by inhibiting PI3K/AKT-dependent phosphomannose isomerase publication-title: Front. Pharmacol. contributor: fullname: Ma – volume: 79 start-page: 171 year: 2018 end-page: 183 ident: bb0195 article-title: Review of the structural characterization, quality evaluation, and industrial application of Lycium barbarum polysaccharides publication-title: Trends Food Sci. Technol. contributor: fullname: Qin – volume: 159 start-page: 137 year: 2014 end-page: 142 ident: bb0190 article-title: Structural characterization of LbGp1 from the fruits of Lycium barbarum L publication-title: Food Chem. contributor: fullname: Huang – volume: 35 start-page: 162 year: 2016 end-page: 166 ident: bb0210 article-title: Study on the antioxidant activity and protective effect on mitochondria of Lycium ruthenicum functional ingredients publication-title: Sci. Technol. Food Ind. contributor: fullname: Zhao – volume: 16 start-page: 2817 year: 2023 end-page: 2830 ident: bb0050 article-title: Research progress of cordyceps sinensis and its fermented mycelium products on ameliorating renal fibrosis by reducing epithelial-to-mesenchymal transition publication-title: J. Inflamm. Res. contributor: fullname: Li – volume: 19 start-page: 1047 year: 2013 end-page: 1053 ident: bb0120 article-title: Origin and function of myofibroblasts in kidney fibrosis publication-title: Nat. Med. contributor: fullname: Kalluri – volume: 270 year: 2021 ident: bb0150 article-title: Oral absorption characteristics and mechanisms of a pectin-type polysaccharide from Smilax china L. across the intestinal epithelium publication-title: Carbohydr. Polym. contributor: fullname: Wang – volume: 595 year: 2020 ident: bb0130 article-title: 2-Phenoxyethanol: a novel reagent for improved sensitivity of carbohydrate quantification publication-title: Anal. Biochem. contributor: fullname: Matur – volume: 35 start-page: 1062 year: 2015 end-page: 1069 ident: bb0325 article-title: Regulation of renal fibrosis by macrophage polarization publication-title: Cell. Physiol. Biochem. contributor: fullname: Zheng – start-page: 185 year: 2001 end-page: 190 ident: bb0180 article-title: Chemical structure and immunoactivity of the glycoconjugates and their glycan chains from the fruit of Lycium barbarum L publication-title: Chin. J. Pharmacol. Toxicol. contributor: fullname: Chunhui – volume: 328 year: 2024 ident: bb0275 article-title: Structural characterization and osteogenic differentiation-promoting activity of polysaccharide purified from Chroogomphus rutilus publication-title: Carbohydr. Polym. contributor: fullname: Wang – volume: 3 year: 2021 ident: bb0290 article-title: Biosynthesis of exopolysaccharide and structural characterization by Lacticaseibacillus paracasei ZY-1 isolated from Tibetan kefir publication-title: Food Chem. Mol. Sci. contributor: fullname: Li – volume: 6 start-page: 628 year: 2015 ident: bb0235 article-title: Structural characterization of a mixed-linkage glucan deficient mutant reveals alteration in cellulose microfibril orientation in rice coleoptile mesophyll cell walls publication-title: Front. Plant Sci. contributor: fullname: Vega-Sánchez – volume: 245 year: 2023 ident: bb0270 article-title: The structure, characterization and immunomodulatory potential of exopolysaccharide produced by Planococcus rifietoensis AP-5 from deep-sea sediments of the Northwest Pacific publication-title: Int. J. Biol. Macromol. contributor: fullname: Bao – volume: 276 year: 2022 ident: bb0085 article-title: Novel pectin-like polysaccharide from Panax notoginseng attenuates renal tubular cells fibrogenesis induced by TGF-β publication-title: Carbohydr. Polym. contributor: fullname: Ding – volume: 116 year: 2019 ident: bb0105 article-title: Lycium barbarum polysaccharides attenuate rat anti-Thy-1 glomerulonephritis through mediating pyruvate dehydrogenase publication-title: Biomed. Pharmacother. contributor: fullname: Gu – volume: 16 start-page: 194 year: 2020 end-page: 203 ident: bb0155 article-title: Ruxolitinib alleviates renal interstitial fibrosis in UUO mice publication-title: Int. J. Biol. Sci. contributor: fullname: Zhao – volume: 157 start-page: 82 year: 2016 end-page: 90 ident: bb0100 article-title: Lycium barbarum polysaccharides ameliorates renal injury and inflammatory reaction in alloxan-induced diabetic nephropathy rabbits publication-title: Life Sci. contributor: fullname: Luo – volume: 30 start-page: 9221 year: 2023 end-page: 9239 ident: bb0230 article-title: Interactions between non-cellulosic plant cell wall polysaccharides and cellulose emerging from adsorption studies publication-title: Cellulose contributor: fullname: Zdunek – volume: 60 start-page: 9424 year: 2012 end-page: 9429 ident: bb0205 article-title: Structural characterization of an arabinogalactan-protein from the fruits of Lycium ruthenicum publication-title: J. Agric. Food Chem. contributor: fullname: Du – volume: 107 start-page: 825 year: 2018 end-page: 832 ident: bb0305 article-title: Digestive behavior of Dendrobium huoshanense polysaccharides in the gastrointestinal tracts of mice publication-title: Int. J. Biol. Macromol. contributor: fullname: Luo – volume: 268 year: 2024 ident: bb0070 article-title: Ganoderma lucidum: multifaceted mechanisms to combat diabetes through polysaccharides and triterpenoids: a comprehensive review publication-title: Int. J. Biol. Macromol. contributor: fullname: Elbendary – volume: 170 year: 2024 ident: bb0010 article-title: Natural products in traditional Chinese medicine: molecular mechanisms and therapeutic targets of renal fibrosis and state-of-the-art drug delivery systems publication-title: Biomed. Pharmacother. contributor: fullname: Huang – volume: 16 start-page: 895 year: 2023 ident: bb0125 article-title: Isolation, purification, and structural characterization of polysaccharides from Codonopsis pilosula and their anti-tumor bioactivity by immunomodulation publication-title: Pharmaceuticals contributor: fullname: Dong – volume: 84 year: 2023 ident: bb0115 article-title: Combination of chemotherapy with low-dose doxorubicin/Lycium barbarum polysaccharide and photothermal therapy with polypyrrole nanoparticles for treating breast cancer publication-title: J. Drug Deliv. Sci. Technol. contributor: fullname: Han – start-page: 260 year: 2020 end-page: 261 ident: bb0090 article-title: Committee for the Pharmacopoeia of China, Chinese Pharmacopoeia Part I contributor: fullname: C.P. Commission – volume: 147 start-page: 114 year: 2016 end-page: 124 ident: bb0165 article-title: Structure characterization, chemical and enzymatic degradation, and chain conformation of an acidic polysaccharide from Lycium barbarum L publication-title: Carbohydr. Polym. contributor: fullname: Gao – volume: 215 start-page: 541 year: 2022 end-page: 549 ident: bb0145 article-title: Study on pharmacokinetics and tissue distribution of Polygonatum sibiricum polysaccharide in rats by fluorescence labeling publication-title: Int. J. Biol. Macromol. contributor: fullname: Qian – volume: 235 start-page: 5787 year: 2020 end-page: 5795 ident: bb0020 article-title: The effect of lncRNA-ARAP1-AS2/ARAP1 on high glucose-induced cytoskeleton rearrangement and epithelial–mesenchymal transition in human renal tubular epithelial cells publication-title: J. Cell. Physiol. contributor: fullname: Fan – volume: 48 start-page: 1715 year: 2020 end-page: 1729 ident: bb0045 article-title: Pterostilbene, a bioactive component of blueberries, alleviates renal interstitial fibrosis by inhibiting macrophage-myofibroblast transition, the American journal of publication-title: Chin. Med. contributor: fullname: Fu – volume: 215 start-page: 307 year: 2019 end-page: 315 ident: bb0240 article-title: Preliminary characterization, antioxidant and α-glucosidase inhibitory activities of polysaccharides from Mallotus furetianus publication-title: Carbohydr. Polym. contributor: fullname: Li – volume: 98 year: 2021 ident: bb0035 article-title: Natural killer T cell/IL-4 signaling promotes bone marrow-derived fibroblast activation and M2 macrophage-to-myofibroblast transition in renal fibrosis publication-title: Int. Immunopharmacol. contributor: fullname: Wen – volume: 278 year: 2022 ident: bb0245 article-title: Structure identification of a polysaccharide in mushroom Lingzhi spore and its immunomodulatory activity publication-title: Carbohydr. Polym. contributor: fullname: Yang – volume: 13 year: 2022 ident: bb0005 article-title: The role of the macrophage-to-myofibroblast transition in renal fibrosis publication-title: Front. Immunol. contributor: fullname: Yan – volume: 9 year: 2023 ident: bb0315 article-title: Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition publication-title: Heliyon contributor: fullname: Zuo – volume: 170 start-page: 22 year: 2015 ident: 10.1016/j.ijbiomac.2024.134491_bb0170 article-title: Sulphation pattern analysis of chemically sulphated polysaccharide LbGp1 from Lycium barbarum by GC–MS publication-title: Food Chem. doi: 10.1016/j.foodchem.2014.08.024 contributor: fullname: Sun – volume: 9 issue: 11 year: 2023 ident: 10.1016/j.ijbiomac.2024.134491_bb0315 article-title: Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition publication-title: Heliyon doi: 10.1016/j.heliyon.2023.e21882 contributor: fullname: Xu – volume: 116 year: 2019 ident: 10.1016/j.ijbiomac.2024.134491_bb0105 article-title: Lycium barbarum polysaccharides attenuate rat anti-Thy-1 glomerulonephritis through mediating pyruvate dehydrogenase publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2019.109020 contributor: fullname: Lu – start-page: 185 year: 2001 ident: 10.1016/j.ijbiomac.2024.134491_bb0180 article-title: Chemical structure and immunoactivity of the glycoconjugates and their glycan chains from the fruit of Lycium barbarum L publication-title: Chin. J. Pharmacol. Toxicol. contributor: fullname: Chunhui – volume: 159 start-page: 137 year: 2014 ident: 10.1016/j.ijbiomac.2024.134491_bb0190 article-title: Structural characterization of LbGp1 from the fruits of Lycium barbarum L publication-title: Food Chem. doi: 10.1016/j.foodchem.2014.02.171 contributor: fullname: Wang – volume: 15 start-page: 1367747 year: 2024 ident: 10.1016/j.ijbiomac.2024.134491_bb0065 article-title: Lycium barbarum polysaccharide reverses drug resistance in oxaliplatin-resistant colon cancer cells by inhibiting PI3K/AKT-dependent phosphomannose isomerase publication-title: Front. Pharmacol. doi: 10.3389/fphar.2024.1367747 contributor: fullname: Ma – volume: 107 start-page: 825 year: 2018 ident: 10.1016/j.ijbiomac.2024.134491_bb0305 article-title: Digestive behavior of Dendrobium huoshanense polysaccharides in the gastrointestinal tracts of mice publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2017.09.047 contributor: fullname: Xie – volume: 19 start-page: 1047 issue: 8 year: 2013 ident: 10.1016/j.ijbiomac.2024.134491_bb0120 article-title: Origin and function of myofibroblasts in kidney fibrosis publication-title: Nat. Med. doi: 10.1038/nm.3218 contributor: fullname: LeBleu – volume: 16 start-page: 194 issue: 2 year: 2020 ident: 10.1016/j.ijbiomac.2024.134491_bb0155 article-title: Ruxolitinib alleviates renal interstitial fibrosis in UUO mice publication-title: Int. J. Biol. Sci. doi: 10.7150/ijbs.39024 contributor: fullname: Bai – volume: 16 start-page: 2817 year: 2023 ident: 10.1016/j.ijbiomac.2024.134491_bb0050 article-title: Research progress of cordyceps sinensis and its fermented mycelium products on ameliorating renal fibrosis by reducing epithelial-to-mesenchymal transition publication-title: J. Inflamm. Res. doi: 10.2147/JIR.S413374 contributor: fullname: Zhang – volume: 13 year: 2022 ident: 10.1016/j.ijbiomac.2024.134491_bb0005 article-title: The role of the macrophage-to-myofibroblast transition in renal fibrosis publication-title: Front. Immunol. contributor: fullname: Wei – volume: 35 start-page: 1062 issue: 3 year: 2015 ident: 10.1016/j.ijbiomac.2024.134491_bb0325 article-title: Regulation of renal fibrosis by macrophage polarization publication-title: Cell. Physiol. Biochem. doi: 10.1159/000373932 contributor: fullname: Pan – volume: 16 start-page: 895 issue: 6 year: 2023 ident: 10.1016/j.ijbiomac.2024.134491_bb0125 article-title: Isolation, purification, and structural characterization of polysaccharides from Codonopsis pilosula and their anti-tumor bioactivity by immunomodulation publication-title: Pharmaceuticals doi: 10.3390/ph16060895 contributor: fullname: Li – volume: 268 issue: Pt 1 year: 2024 ident: 10.1016/j.ijbiomac.2024.134491_bb0070 article-title: Ganoderma lucidum: multifaceted mechanisms to combat diabetes through polysaccharides and triterpenoids: a comprehensive review publication-title: Int. J. Biol. Macromol. contributor: fullname: Ahmad – volume: 270 year: 2021 ident: 10.1016/j.ijbiomac.2024.134491_bb0150 article-title: Oral absorption characteristics and mechanisms of a pectin-type polysaccharide from Smilax china L. across the intestinal epithelium publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2021.118383 contributor: fullname: Zhang – volume: 30 start-page: 9221 issue: 15 year: 2023 ident: 10.1016/j.ijbiomac.2024.134491_bb0230 article-title: Interactions between non-cellulosic plant cell wall polysaccharides and cellulose emerging from adsorption studies publication-title: Cellulose doi: 10.1007/s10570-023-05442-y contributor: fullname: Pękala – volume: 80 start-page: 672 issue: 3 year: 2010 ident: 10.1016/j.ijbiomac.2024.134491_bb0220 article-title: Extraction, characterization of polysaccharides from lycium barbarum and its effect on bone gene expression in rats publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2009.11.038 contributor: fullname: Zhu – volume: 253 issue: Pt 3 year: 2023 ident: 10.1016/j.ijbiomac.2024.134491_bb0080 article-title: Therapeutic mechanism exploration of polysaccharides from Dendrobium officinale on unilateral ureteral obstruction operation-induced renal fibrosis based on improving oxidative stress injury mediated by AhR/NOX4 pathway publication-title: Int. J. Biol. Macromol. contributor: fullname: Shi – volume: 302 issue: Pt A year: 2023 ident: 10.1016/j.ijbiomac.2024.134491_bb0075 article-title: Structural characterization and protective effect against renal fibrosis of polysaccharide from Ligustrum lucidum Ait publication-title: J. Ethnopharmacol. contributor: fullname: Zhang – volume: 235 start-page: 5787 issue: 7–8 year: 2020 ident: 10.1016/j.ijbiomac.2024.134491_bb0020 article-title: The effect of lncRNA-ARAP1-AS2/ARAP1 on high glucose-induced cytoskeleton rearrangement and epithelial–mesenchymal transition in human renal tubular epithelial cells publication-title: J. Cell. Physiol. doi: 10.1002/jcp.29512 contributor: fullname: Li – volume: 215 start-page: 307 year: 2019 ident: 10.1016/j.ijbiomac.2024.134491_bb0240 article-title: Preliminary characterization, antioxidant and α-glucosidase inhibitory activities of polysaccharides from Mallotus furetianus publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2019.03.099 contributor: fullname: Chen – volume: 24 start-page: 752 issue: 6 year: 2021 ident: 10.1016/j.ijbiomac.2024.134491_bb0060 article-title: Verbascoside alleviates renal fibrosis in unilateral ureteral obstruction rats by inhibiting macrophage infiltration publication-title: Iran. J. Basic Med. Sci. contributor: fullname: Zhang – volume: 201 start-page: 630 year: 2022 ident: 10.1016/j.ijbiomac.2024.134491_bb0260 article-title: A natural selenium polysaccharide from Pleurotus ostreatus: structural elucidation, anti-gastric cancer and anti-colon cancer activity in vitro publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2022.01.101 contributor: fullname: Zhang – volume: 276 year: 2022 ident: 10.1016/j.ijbiomac.2024.134491_bb0085 article-title: Novel pectin-like polysaccharide from Panax notoginseng attenuates renal tubular cells fibrogenesis induced by TGF-β publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2021.118772 contributor: fullname: Huang – volume: 3 year: 2021 ident: 10.1016/j.ijbiomac.2024.134491_bb0290 article-title: Biosynthesis of exopolysaccharide and structural characterization by Lacticaseibacillus paracasei ZY-1 isolated from Tibetan kefir publication-title: Food Chem. Mol. Sci. contributor: fullname: Xiao – start-page: 260 year: 2020 ident: 10.1016/j.ijbiomac.2024.134491_bb0090 contributor: fullname: C.P. Commission – volume: 328 year: 2024 ident: 10.1016/j.ijbiomac.2024.134491_bb0275 article-title: Structural characterization and osteogenic differentiation-promoting activity of polysaccharide purified from Chroogomphus rutilus publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2023.121709 contributor: fullname: Zhou – volume: 10 start-page: 63 issue: 1 year: 2021 ident: 10.1016/j.ijbiomac.2024.134491_bb0250 article-title: Purification, structural elucidation, and in vitro antitumor effects of novel polysaccharides from Bangia fuscopurpurea publication-title: Food Sci. Human Wellness doi: 10.1016/j.fshw.2020.05.003 contributor: fullname: Wu – volume: 60 start-page: 9424 issue: 37 year: 2012 ident: 10.1016/j.ijbiomac.2024.134491_bb0205 article-title: Structural characterization of an arabinogalactan-protein from the fruits of Lycium ruthenicum publication-title: J. Agric. Food Chem. doi: 10.1021/jf302619c contributor: fullname: Peng – volume: 147 start-page: 114 year: 2016 ident: 10.1016/j.ijbiomac.2024.134491_bb0165 article-title: Structure characterization, chemical and enzymatic degradation, and chain conformation of an acidic polysaccharide from Lycium barbarum L publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2016.03.087 contributor: fullname: Liu – volume: 84 year: 2023 ident: 10.1016/j.ijbiomac.2024.134491_bb0115 article-title: Combination of chemotherapy with low-dose doxorubicin/Lycium barbarum polysaccharide and photothermal therapy with polypyrrole nanoparticles for treating breast cancer publication-title: J. Drug Deliv. Sci. Technol. contributor: fullname: Sun – volume: 35 start-page: 162 year: 2016 ident: 10.1016/j.ijbiomac.2024.134491_bb0210 article-title: Study on the antioxidant activity and protective effect on mitochondria of Lycium ruthenicum functional ingredients publication-title: Sci. Technol. Food Ind. contributor: fullname: Xia – volume: 227 year: 2020 ident: 10.1016/j.ijbiomac.2024.134491_bb0160 article-title: Structural characterization and antioxidant activity of a new polysaccharide from Bletilla striata fibrous roots publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2019.115362 contributor: fullname: Chen – volume: 215 start-page: 541 year: 2022 ident: 10.1016/j.ijbiomac.2024.134491_bb0145 article-title: Study on pharmacokinetics and tissue distribution of Polygonatum sibiricum polysaccharide in rats by fluorescence labeling publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2022.06.078 contributor: fullname: Bi – volume: 30 start-page: 3017 issue: 9 year: 2022 ident: 10.1016/j.ijbiomac.2024.134491_bb0300 article-title: P2Y12 inhibitor clopidogrel inhibits renal fibrosis by blocking macrophage-to-myofibroblast transition publication-title: Mol. Ther. doi: 10.1016/j.ymthe.2022.06.019 contributor: fullname: Chen – volume: 58 start-page: 594 issue: 2 year: 2014 ident: 10.1016/j.ijbiomac.2024.134491_bb0175 article-title: Effects of superfine grinding on physicochemical and antioxidant properties of Lycium barbarum polysaccharides publication-title: LWT Food Sci. Technol. doi: 10.1016/j.lwt.2014.04.020 contributor: fullname: Zhang – volume: 14 start-page: 2677 issue: 12 year: 2022 ident: 10.1016/j.ijbiomac.2024.134491_bb0110 article-title: Combined photothermal therapy and Lycium barbarum polysaccharide for topical administration to improve the efficacy of doxorubicin in the treatment of breast cancer publication-title: Pharmaceutics doi: 10.3390/pharmaceutics14122677 contributor: fullname: Sun – volume: 278 year: 2022 ident: 10.1016/j.ijbiomac.2024.134491_bb0245 article-title: Structure identification of a polysaccharide in mushroom Lingzhi spore and its immunomodulatory activity publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2021.118939 contributor: fullname: Sheng – volume: 79 start-page: 171 year: 2018 ident: 10.1016/j.ijbiomac.2024.134491_bb0195 article-title: Review of the structural characterization, quality evaluation, and industrial application of Lycium barbarum polysaccharides publication-title: Trends Food Sci. Technol. doi: 10.1016/j.tifs.2018.07.016 contributor: fullname: Wu – volume: 157 start-page: 220 year: 2020 ident: 10.1016/j.ijbiomac.2024.134491_bb0285 article-title: Influences of drying methods on the structural, physicochemical and antioxidant properties of exopolysaccharide from Lactobacillus helveticus MB2-1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2020.04.196 contributor: fullname: Xiao – volume: 28 start-page: 2053 issue: 7 year: 2017 ident: 10.1016/j.ijbiomac.2024.134491_bb0015 article-title: Macrophage-to-Myofibroblast transition contributes to interstitial fibrosis in chronic renal allograft injury publication-title: J. Am. Soc. Nephrol.: JASN doi: 10.1681/ASN.2016050573 contributor: fullname: Wang – volume: 245 year: 2023 ident: 10.1016/j.ijbiomac.2024.134491_bb0270 article-title: The structure, characterization and immunomodulatory potential of exopolysaccharide produced by Planococcus rifietoensis AP-5 from deep-sea sediments of the Northwest Pacific publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2023.125452 contributor: fullname: Hu – volume: 161 start-page: 42 year: 2017 ident: 10.1016/j.ijbiomac.2024.134491_bb0280 article-title: Structural elucidation and antioxidant activity a novel Se-polysaccharide from Se-enriched Grifola frondosa publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2016.12.041 contributor: fullname: Li – volume: 170 year: 2024 ident: 10.1016/j.ijbiomac.2024.134491_bb0010 article-title: Natural products in traditional Chinese medicine: molecular mechanisms and therapeutic targets of renal fibrosis and state-of-the-art drug delivery systems publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2023.116039 contributor: fullname: Song – volume: 229 year: 2022 ident: 10.1016/j.ijbiomac.2024.134491_bb0095 article-title: Immune activities of polysaccharides isolated from Lycium barbarum L. what do we know so far? publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2021.107921 contributor: fullname: Xiao – volume: 157 start-page: 82 year: 2016 ident: 10.1016/j.ijbiomac.2024.134491_bb0100 article-title: Lycium barbarum polysaccharides ameliorates renal injury and inflammatory reaction in alloxan-induced diabetic nephropathy rabbits publication-title: Life Sci. doi: 10.1016/j.lfs.2016.05.045 contributor: fullname: Zhao – volume: 80 start-page: 1161 issue: 4 year: 2010 ident: 10.1016/j.ijbiomac.2024.134491_bb0215 article-title: Structure characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Lycium barbarum L publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2010.01.038 contributor: fullname: Zou – volume: 48 start-page: 1715 issue: 7 year: 2020 ident: 10.1016/j.ijbiomac.2024.134491_bb0045 article-title: Pterostilbene, a bioactive component of blueberries, alleviates renal interstitial fibrosis by inhibiting macrophage-myofibroblast transition, the American journal of publication-title: Chin. Med. doi: 10.1142/S0192415X20500858 contributor: fullname: Feng – volume: 129 start-page: 295 year: 2018 ident: 10.1016/j.ijbiomac.2024.134491_bb0040 article-title: Targeting renal fibrosis: mechanisms and drug delivery systems publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2017.12.019 contributor: fullname: Nastase – volume: 13 issue: 635 year: 2020 ident: 10.1016/j.ijbiomac.2024.134491_bb0025 article-title: Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis publication-title: Sci. Signal. doi: 10.1126/scisignal.aaz2597 contributor: fullname: Lovisa – volume: 2 year: 2021 ident: 10.1016/j.ijbiomac.2024.134491_bb0225 article-title: Immunomodulatory potential of polysaccharides derived from plants and microbes: a narrative review publication-title: Carbohydr. Polym. Technol. Appl. contributor: fullname: Sindhu – volume: 82 start-page: 696 year: 2016 ident: 10.1016/j.ijbiomac.2024.134491_bb0185 article-title: Structure identification of a polysaccharide purified from Lycium barbarium fruit publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2015.10.069 contributor: fullname: Yuan – volume: 52 issue: 2 year: 2019 ident: 10.1016/j.ijbiomac.2024.134491_bb0310 article-title: QingBai decoction regulates intestinal permeability of dextran sulphate sodium-induced colitis through the modulation of notch and NF-κB signalling publication-title: Cell Prolif. doi: 10.1111/cpr.12547 contributor: fullname: Lin – volume: 324 year: 2024 ident: 10.1016/j.ijbiomac.2024.134491_bb0255 article-title: Structural elucidation of a highly branched α-D-glucan from Huangjiu and its hepatoprotective activity via gut microbiome regulation and intestinal barrier repairment publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2023.121423 contributor: fullname: Yang – volume: 139 year: 2021 ident: 10.1016/j.ijbiomac.2024.134491_bb0030 article-title: Small molecules against the origin and activation of myofibroblast for renal interstitial fibrosis therapy publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2021.111386 contributor: fullname: Feng – volume: 2020 start-page: 1903056 year: 2020 ident: 10.1016/j.ijbiomac.2024.134491_bb0140 article-title: Characterization of polysaccharides extracted from pulps and seeds of Crataegus azarolus L. var. aronia: preliminary structure, antioxidant, antibacterial, α-amylase, and acetylcholinesterase inhibition properties publication-title: Oxid. Med. Cell. Longev. doi: 10.1155/2020/1903056 contributor: fullname: Rjeibi – volume: 13 start-page: 1290 issue: 3 year: 2021 ident: 10.1016/j.ijbiomac.2024.134491_bb0330 article-title: Schistosoma japonicum-derived peptide SJMHE1 promotes peripheral nerve repair through a macrophage-dependent mechanism publication-title: Am. J. Transl. Res. contributor: fullname: Ma – volume: 43 start-page: 199 year: 2015 ident: 10.1016/j.ijbiomac.2024.134491_bb0200 article-title: Characterization and comparison of bioactive polysaccharides from the tubers of Gymnadenia conopsea publication-title: Food Hydrocoll. doi: 10.1016/j.foodhyd.2014.05.015 contributor: fullname: Lin – volume: 17 start-page: 22508 issue: 22 year: 2023 ident: 10.1016/j.ijbiomac.2024.134491_bb0295 article-title: Precisely regulating M2 subtype macrophages for renal fibrosis resolution publication-title: ACS Nano doi: 10.1021/acsnano.3c05998 contributor: fullname: Luo – volume: 13 year: 2022 ident: 10.1016/j.ijbiomac.2024.134491_bb0055 article-title: Esaxerenone inhibits the macrophage-to-myofibroblast transition through mineralocorticoid receptor/TGF-β1 pathway in mice induced with aldosterone publication-title: Front. Immunol. doi: 10.3389/fimmu.2022.948658 contributor: fullname: Qiang – volume: 595 year: 2020 ident: 10.1016/j.ijbiomac.2024.134491_bb0130 article-title: 2-Phenoxyethanol: a novel reagent for improved sensitivity of carbohydrate quantification publication-title: Anal. Biochem. doi: 10.1016/j.ab.2020.113624 contributor: fullname: Rajendar – volume: 222 start-page: 154 year: 2022 ident: 10.1016/j.ijbiomac.2024.134491_bb0135 article-title: Isolation, structure elucidation, and biological activity of polysaccharides from Saussurea involucrata publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2022.09.137 contributor: fullname: Liu – volume: 179 start-page: 407 year: 2021 ident: 10.1016/j.ijbiomac.2024.134491_bb0265 article-title: Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2021.02.191 contributor: fullname: Wang – volume: 6 start-page: 628 year: 2015 ident: 10.1016/j.ijbiomac.2024.134491_bb0235 article-title: Structural characterization of a mixed-linkage glucan deficient mutant reveals alteration in cellulose microfibril orientation in rice coleoptile mesophyll cell walls publication-title: Front. Plant Sci. doi: 10.3389/fpls.2015.00628 contributor: fullname: Smith-Moritz – volume: 98 year: 2021 ident: 10.1016/j.ijbiomac.2024.134491_bb0035 article-title: Natural killer T cell/IL-4 signaling promotes bone marrow-derived fibroblast activation and M2 macrophage-to-myofibroblast transition in renal fibrosis publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2021.107907 contributor: fullname: Liu – volume: 19 start-page: 3075 issue: 9 year: 2022 ident: 10.1016/j.ijbiomac.2024.134491_bb0320 article-title: Kidney-targeted drug delivery system based on metformin-grafted chitosan for renal fibrosis therapy publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.1c00827 contributor: fullname: Sun |
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| Title | Novel glucomannan-like polysaccharide from Lycium barbarum L. ameliorates renal fibrosis via blocking macrophage-to-myofibroblasts transition |
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