Synthesis of novel imidazolidinones from hexose-peptide adducts: model studies of the Maillard reaction with possible significance in protein glycation

Novel hexose-related imidazolidin-4-ones are prepared by intramolecular rearrangements of monosaccharide esters in which D-mannose, D-glucose, or D-galactose are linked through their C-6 hydroxy groups to the endogenous opioid pentapeptide, leucine-enkephalin.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 16; pp. 1663 - 1664
Main Authors Horvat, S, Varga-Defterdarovic, L, Roscic, M, Horvat, J
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.08.1998
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
DIABETIC COMPLICATIONS
COLLAGEN
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Summary:Novel hexose-related imidazolidin-4-ones are prepared by intramolecular rearrangements of monosaccharide esters in which D-mannose, D-glucose, or D-galactose are linked through their C-6 hydroxy groups to the endogenous opioid pentapeptide, leucine-enkephalin.
ISSN:1359-7345
1364-548X
DOI:10.1039/a803099e