The role of mixed lineage kinase 3 (MLK3) in cancers

Mixed lineage kinase 3 (MLK3) is a serine/threonine kinase family member of mitogen activated protein kinase kinase kinases (MAP3Ks). MLK3 has been implicated in the regulation of tumor cell proliferation, differentiation, migration, invasion, and apoptosis depending on the cellular contexts. Notwit...

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Bibliographic Details
Published inPharmacology & therapeutics (Oxford) Vol. 238; p. 108269
Main Authors Ramachandraiah, Karna, Thylur Puttalingaiah, Ramesh
Format Journal Article
LanguageEnglish
Published England 01.10.2022
Subjects
Humans
MAP Kinase Kinase Kinases - metabolism
Mitogen-Activated Protein Kinase Kinase Kinase 11
Neoplasms
Protein Serine-Threonine Kinases
Serine
Signaling pathways
MLK3
Therapeutic targeting
Cancer
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Summary:Mixed lineage kinase 3 (MLK3) is a serine/threonine kinase family member of mitogen activated protein kinase kinase kinases (MAP3Ks). MLK3 has been implicated in the regulation of tumor cell proliferation, differentiation, migration, invasion, and apoptosis depending on the cellular contexts. Notwithstanding the involvement of MLK3 in several cancers, the precise roles of MLK3 are not completely understood. This review evaluates the molecular mechanisms and signaling pathways associated with MLK3, which play a major role in malignancies that include breast, cervical, colorectal, gastric and prostate cancer. Since early detection of cancer is critical, this review discusses the potential of MLK3 as a predictive biomarker, which could likely help in clinical decision-making. Importantly, the efficacy of targeting MLK3 via different therapeutic approaches is also explored.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0163-7258
1879-016X
DOI:10.1016/j.pharmthera.2022.108269