Epigenetics of human parathyroid tumors

Parathyroid tumors are common endocrine neoplasia associated with primary hyperparathyroidism, a metabolic disorder sustained by parathormone hypersecretion. The epigenetic scenario in parathyroid tumors is beginning to be decoded. Here, main findings are reviewed: hypermethylation of specific DNA C...

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Bibliographic Details
Published inInternational journal of endocrine oncology Vol. 4; no. 2; pp. 103 - 111
Main Authors Chiara, Verdelli, Sabrina, Corbetta
Format Journal Article
LanguageEnglish
Published London Future Medicine Ltd 01.05.2017
Subjects
Cancer
Deoxyribonucleic acid
DNA
DNA methylation
Enzymes
Epigenetics
Gene expression
Genomes
histone
histone methyltransferases
Investigations
MicroRNAs
miRNAs
Mutation
Neuroendocrine tumors
parathyroid tumors
primary hyperparathyroidism
Tumors
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Summary:Parathyroid tumors are common endocrine neoplasia associated with primary hyperparathyroidism, a metabolic disorder sustained by parathormone hypersecretion. The epigenetic scenario in parathyroid tumors is beginning to be decoded. Here, main findings are reviewed: hypermethylation of specific DNA CpG islands has been described, despite global DNA promoter hypomethylation was not detectable; embryonic-related miRNAs, belonging to the C19MC and miR-371-373 clusters, and miR-296, are deregulated; expression of histone H1.2 and H2B is increased; expression of histone methyltransferase EZH2, BMI1 and RIZ1 is impaired; the tumor suppressor , and gene products, key molecules in parathyroid tumorigenesis, may be involved in epigenetic aberrant changes. Epigenetic changes are more frequent and more consistent in parathyroid malignancies, and positively correlated with severity of primary hyperparathyroidism.
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ISSN:2045-0869
2045-0877
DOI:10.2217/ije-2017-0002