Synthesis of 17 alpha-amino-5 alpha-androst-2-ene from epiandrosterone

17 alpha-Amino-5 alpha-androst-2-ene was synthesized from epiandrosterone via formation of the tosylate followed by nucleophilic substitution by azide and reduction with LiAlH4. The structures of the products were proved by NMR and IR spectroscopy and mass spectrometry.

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Bibliographic Details
Published inChemistry of natural compounds Vol. 42; no. 3; pp. 313 - 315
Main Authors Merlani, M. I., Amiranashvili, L. Sh, Kemertelidze, E. P., Papadopoulos, K., Yannakopulu, E.
Format Journal Article
LanguageEnglish
Published NEW YORK Springer Nature 01.05.2006
Subjects
Chemistry
Chemistry, Medicinal
Chemistry, Organic
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical Sciences
Science & Technology
synthesis
BINDING
aminosteroids
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Summary:17 alpha-Amino-5 alpha-androst-2-ene was synthesized from epiandrosterone via formation of the tosylate followed by nucleophilic substitution by azide and reduction with LiAlH4. The structures of the products were proved by NMR and IR spectroscopy and mass spectrometry.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-006-0108-4