Long-term feeding studies in mice fed a diet containing irradiated fish. I. Multigeneration reproduction, mutagenicity, teratology, and longevity studies

A wholesomeness feeding study was carried out in mice fed equal amounts of cod or redfish, comprising 45% of the diet. Three groups of animals received either irradiated [1.75 kGy (175 krad)] fish, non-irradiated fish or stock ration. A 90-day subchronic study, a multigeneration reproduction, a domi...

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Bibliographic Details
Published inToxicology letters Vol. 7; no. 2; pp. 97 - 101
Main Authors Van Petten, L.E, Calkins, J.E, McConnell, R.F, Gottschalk, H.M, Elias, P.S
Format Journal Article
LanguageEnglish
Published Netherlands 01.12.1980
Subjects
Animals
aquatic organisms
Congenital Abnormalities - etiology
Diet
diet-related diseases
Female
Fish Products
Food Irradiation - adverse effects
human nutrition
Longevity
Male
Mice
Mutation
Reproduction
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Summary:A wholesomeness feeding study was carried out in mice fed equal amounts of cod or redfish, comprising 45% of the diet. Three groups of animals received either irradiated [1.75 kGy (175 krad)] fish, non-irradiated fish or stock ration. A 90-day subchronic study, a multigeneration reproduction, a dominant lethality and a teratology study were carried out together with an 80-week oncogenic study on the F1 generation. No adverse effects were noted on growth, reproduction and litter behaviour, in relation to dominant lethality, teratogenicity or oncogenicity.
ISSN:0378-4274
1879-3169
DOI:10.1016/0378-4274(80)90039-9