Reaction of carbon disulfide with cyanoacetic acid hydrazide: Novel synthesis of thiazole and thiazolo[4,5-c]pyrazole

The reaction of cyanoacetic acid hydrazide with carbon disulfide in basic dimethylformamide afforded the potassium thiocarbamate 2 which underwent ready heterocyclization upon its reaction with alpha-haloketones to give the thiazole derivatives 4 and 23.

Saved in:
Bibliographic Details
Published inJournal of chemical research. Synopses no. 1; pp. 10 - 13
Main Authors Mohareb, RM, Aziz, SI, Abdel-Sayed, NI, El-Banna, AH
Format Journal Article
LanguageEnglish
Published NORTHWOOD Science Reviews Ltd 01.01.1999
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
HETEROCYCLIC SYNTHESIS
THIAZOLIDINONES
DERIVATIVES
IMIDAZOLIDINONES
THIOPHENE
RING
Online AccessGet more information

Cover

More Information
Summary:The reaction of cyanoacetic acid hydrazide with carbon disulfide in basic dimethylformamide afforded the potassium thiocarbamate 2 which underwent ready heterocyclization upon its reaction with alpha-haloketones to give the thiazole derivatives 4 and 23.
ISSN:0308-2342
DOI:10.1039/a802611d