Zinc and copper complexes with azacrown ethers and their comparative stability in vitro and in vivo

Copper-based radiopharmaceuticals are of high interest these days owing to the decay properties of copper radioisotopes. In contrast, labeled zinc compounds have been less studied for applications in nuclear medicine. In this study, the stability of labeled zinc and copper complexes with two azacrow...

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Published inDalton transactions : an international journal of inorganic chemistry Vol. 49; no. 19; pp. 6249 - 6258
Main Authors Aleshin, Gleb Yu, Egorova, Bayirta V, Priselkova, Anna B, Zamurueva, Lyubov S, Khabirova, Sofia Yu, Zubenko, Anastasia D, Karnoukhova, Valentina A, Fedorova, Olga A, Kalmykov, Stepan N
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 19.05.2020
Subjects
Biomedical materials
Coordination compounds
Copper
Copper compounds
Crystallography
Ethers
In vivo methods and tests
Nuclear medicine
Radioisotopes
Serum proteins
Stability
Titration
Zinc compounds
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Summary:Copper-based radiopharmaceuticals are of high interest these days owing to the decay properties of copper radioisotopes. In contrast, labeled zinc compounds have been less studied for applications in nuclear medicine. In this study, the stability of labeled zinc and copper complexes with two azacrown ether ligands was investigated and compared. Then, the in vitro and in vivo stability of the studied zinc complexes was demonstrated, with the complexes showing promise for biomedical applications. In contrast, analogous copper complexes quickly dissociated in the presence of serum proteins. Furthermore, a simple method for the production of radiochemically pure 65Zn was proposed, and the opportunity for its use as a surrogate radionuclide for research into potential zinc-containing radiopharmaceuticals was demonstrated.
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ISSN:1477-9226
1477-9234
DOI:10.1039/d0dt00645a