Synthesis of 4-Formyl-3-cyclopentene-1,1,2-tricarbonitriles

beta,beta,gamma,gamma-Tetracyanoalkanones react with acrolein at a high rate to afford the corresponding 2-substituted 4-formyl-3-cyclopentene-1,1,2-tricarbonitriles in high yields. The reaction occurs under mild conditions and is quite applicable for modification of natural and biologically active...

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Bibliographic Details
Published inRussian journal of organic chemistry Vol. 41; no. 12; pp. 1757 - 1763
Main Authors Sheverdov, VP, Ershov, OV, Eremkin, AV, Nasakin, OE, Bardasov, IN, Tafeenko, VA
Format Journal Article
LanguageEnglish
Published NEW YORK Springer Nature 01.12.2005
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CHEMISTRY
1,1,2,2-TETRACYANOETHANE
TETRACYANOETHYLATED KETONES
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Summary:beta,beta,gamma,gamma-Tetracyanoalkanones react with acrolein at a high rate to afford the corresponding 2-substituted 4-formyl-3-cyclopentene-1,1,2-tricarbonitriles in high yields. The reaction occurs under mild conditions and is quite applicable for modification of natural and biologically active compounds possessing an R'CHC(O)CR3 fragment to obtain their derivatives containing three cyano groups.
ISSN:1070-4280
1608-3393
DOI:10.1007/s11178-006-0034-8