Regioselective modification of the sugar moiety in pyrimidine nucleosides via a 4 ',5 '-dehydro-2 ',3 '-anhydrouridine intermediate

3'-Substituted pyrimidine nucleoside derivatives are obtained in moderate to high yields by the reaction of 1-(2',3'-anhydro-5'-deoxy-4',5'-didehydro-alpha-L-erythro-pentofuranosyl)uracil with nucleophiles without the formation of the corresponding 2'-adduct.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 18; pp. 1827 - 1828
Main Authors Hirota, K, Takasu, H, Tsuji, Y, Sajiki, H
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.09.1999
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
ANTIVIRAL ACTIVITY
INHIBITORS
HUMAN-IMMUNODEFICIENCY-VIRUS
ANALOGS
DERIVATIVES
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Summary:3'-Substituted pyrimidine nucleoside derivatives are obtained in moderate to high yields by the reaction of 1-(2',3'-anhydro-5'-deoxy-4',5'-didehydro-alpha-L-erythro-pentofuranosyl)uracil with nucleophiles without the formation of the corresponding 2'-adduct.
ISSN:1359-7345
1364-548X
DOI:10.1039/a905608d