PEGylated graphene oxide/Fe3O4 nanocomposite: Synthesis, characterization, and evaluation of its performance as de novo drug delivery nanosystem

This paper describes the development of mitoxantrone-loaded PEGylated graphene oxide/magnetite nanoparticles (PEG-GO/Fe3O4-MTX), and investigation of its preliminary drug delivery performance. For this, the GO was synthesized through oxidizing graphite powder, and subsequently carboxylated using a s...

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Published inBio-medical materials and engineering Vol. 29; no. 2; pp. 177 - 190
Main Authors Jafarizad, Abbas, Taghizadehgh-Alehjougi, Ali, Eskandani, Morteza, Hatamzadeh, Maryam, Abbasian, Mojtaba, Mohammad-Rezaei, Rahim, Mohammadzadeh, Maryam, Toğar, Başak, Jaymand, Mehdi
Format Journal Article
LanguageEnglish
Published Netherlands IOS Press BV 01.01.2018
Subjects
Anchoring
Biocompatibility
Cancer
Cytotoxicity
Drug delivery
Drug delivery systems
Esterification
Graphene
Iron oxides
Magnetite
Mitoxantrone
Nanocomposites
Nanoparticles
Oxidation
pH effects
Polyethylene glycol
Powder
Sonication
Substitution reactions
Synthesis
Therapy
Toxicity
mitoxantrone
magnetite nanoparticles
Graphene oxide
cancer chemotherapy
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Summary:This paper describes the development of mitoxantrone-loaded PEGylated graphene oxide/magnetite nanoparticles (PEG-GO/Fe3O4-MTX), and investigation of its preliminary drug delivery performance. For this, the GO was synthesized through oxidizing graphite powder, and subsequently carboxylated using a substitution nucleophilic reaction. The carboxylated GO (GO-COOH) was then conjugated with amine end-caped PEG chains by Steglich esterification. Afterward, GO-PEG/Fe3O4 nanocomposite was synthesized through the anchoring of Fe3O4 nanoparticles onto the surface of GO-PEG during the sonication. The biocompatibility and MTX-loading capacity of the synthesized GO-PEG/Fe3O4 nanocomposite were evaluated. The pH dependent drug release behavior and cytotoxicity effect of the MTX-loaded GO-PEG/Fe3O4 nanocomposite were also studied. According to biocompatibility, pH dependent drug release behavior as well as superior physicochemical and biological characteristics of graphene and magnetite nanoparticles, it is expected that the GO-PEG/Fe3O4 nanocomposite may be applied as de novo drug delivery system (DDS) for cancer therapy using both chemo- and photothermal therapy approaches.
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ISSN:0959-2989
1878-3619
DOI:10.3233/BME-171721