An enantioselective synthesis of 2-alkyl-3-phenyltropanes by an asymmetric 1,3-dipolar cycloaddition reaction

A method for gaining access to 2-alkyl-3-phenyl-substituted tropanes using the chiral dipolarophile (R)-p-tolyl vinyl sulfoxide in the asymmetric 1,3-dipolar cycloaddition reaction with the oxidopyridinium betaine 4 is described.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 19; pp. 1875 - 1876
Main Authors Araldi, GL, Prakash, KRC, George, C, Kozikowski, AP
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 1997
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
CHEMISTRY
COCAINE
ACID METHYL-ESTERS
LIGANDS
ANALOGS
AFFINITY
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Summary:A method for gaining access to 2-alkyl-3-phenyl-substituted tropanes using the chiral dipolarophile (R)-p-tolyl vinyl sulfoxide in the asymmetric 1,3-dipolar cycloaddition reaction with the oxidopyridinium betaine 4 is described.
ISSN:1359-7345
1364-548X
DOI:10.1039/a704216g