Advance in Cistanche deserticola Y. C. Ma. polysaccharides: Isolation, structural characterization, bioactivities and application: A review

• Published in: International journal of biological macromolecules Vol. 278; no. Pt 2; p. 134786
• Main Authors: Xue, Taotao, Zheng, Dongxuan, Wen, Limei, Hou, Qiang, He, Shengqi, Zhang, Haibo, Gong, Yuehong, Li, Mingjie, Hu, Junping, Yang, Jianhua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2024
• Subjects: Animals; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Biological activity; Cistanche - chemistry; Cistanche deserticola; Extraction methods; Humans; Polysaccharides; Polysaccharides - chemistry; Polysaccharides - isolation & purification; Polysaccharides - pharmacology; Structural characterization; Structure-Activity Relationship; HI; RANKL; Extraction methods; JNK; FT-IR; XRD; MDA; MTT; NF-κB; IFN-γ; Glcp; Th; RG-I; IC50; MAPKs; UV; GlcA; IL; Rhap; DPPH; HPLC-MS; Structural characterization; HMBC; GalUA; MITF; MAPK; IL-6; Ara; Gal; HPSEC; Man; ERK; NO; Cistanche deserticola; FMDV-Ag; Rha; COSY; LPS; Polysaccharides; CREB; DCs; Fuc; OH; Galp; AChE; CD; GC–MS; SOD; RAB27A; Xyl; EDTA; TYR; HPGPC; Biological activity; NMR; TNF-α; MHCII; HMQC; GPC; TRP1/2; ABTS; Glc
• ISSN: 0141-8130; 1879-0003; 1879-0003
• DOI: 10.1016/j.ijbiomac.2024.134786

Cistanche deserticola Y. C. Ma (CD), is mainly distributed in the regions of China (Xinjiang, Inner Mongolia, Gansu), Mongolia, Iran and India. Cistanche deserticola polysaccharide (CDPs), as one of the main components and a crucial bioactive substance of CD, has a variety of pharmacological activities, including immunomodulatory, anti-aging, anti-oxidant, hepatoprotective, anti-osteoporotic, anti-inflammatory, intestinal flora regulatory effects. Many polysaccharides have been successfully obtained in the last three decades from CD. However, there is currently no comprehensive review available concerning CDPs. Considering the importance of CDPs for biological study and drug discovery, the present review aims to systematically summarize the recent major studies on extraction and purification methods of polysaccharides from CD, as well as the characterization of their chemical structure, biological activity, structure-activity relationship, and the application of CDPs in pharmaceutical field. Meanwhile, the shortcomings of CDPs research are further discussed in detail, and new valuable insights for future CDPs research as therapeutic agents and functional foods are proposed. [Display omitted] •Summarized the recent years of Cistanche deserticola polysaccharides•Polysaccharides obtained from Cistanche deserticola exhibit various beneficial biological activities.•The structure-activity relationship and the applications of CDPs were summarized and speculation.•Future research and applications of Cistanche deserticola polysaccharides are discussed.