Ir-catalysed allylic substitution: mechanistic aspects and asymmetric synthesis with phosphorus amidites as ligands

Ir-catalysed allylic alkylations of enantiomerically enriched monosubstituted allylic acetates proceed with up to 79% retention of configuration using P(OPh)(3) as ligand; further evidence supports the assumption of sigma-allyl complexes as intermediates, and high regio- and enantioselectivity in as...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) no. 8; pp. 741 - 742
Main Authors Bartels, B, Helmchen, G
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.04.1999
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
ALKYLATION
COMPLEXES
Online AccessGet full text

Cover

More Information
Summary:Ir-catalysed allylic alkylations of enantiomerically enriched monosubstituted allylic acetates proceed with up to 79% retention of configuration using P(OPh)(3) as ligand; further evidence supports the assumption of sigma-allyl complexes as intermediates, and high regio- and enantioselectivity in asymmetric allylic alkylations of achiral or racemic substrates is achieved with phosphorus amidites as ligands.
ISSN:1359-7345
1364-548X
DOI:10.1039/a900864k