Is There Any Correlation Between De Ritis Ratio and Prostate Cancer in Males Who Underwent Transrectal Prostate Biopsy?

• Published in: Bagcilar Medical Bulletin Vol. 6; no. 1; pp. 66 - 72
• Main Authors: Şahin, Yusuf, Yılmaz, Mehmet, Hacıbey, İbrahim, Filtekin, Yiğit Can, Çolakerol, Aykut, Semerciöz, Atilla, Müslümanoğlu, Ahmet Yaser
• Format: Journal Article
• Language: English
• Published: Bagcilar Galenos Publishing House 01.03.2021; Galenos Yayinevi
• Subjects: alanine aminotransferase; Antigens; aspartate aminotransferase; Biomarkers; Biopsy; Correlation analysis; de ritis ratio; Hepatitis; Hypertension; Medical records; Patients; Prostate cancer; Statistical analysis; Urology
• ISSN: 2547-9431; 2547-9431
• DOI: 10.4274/BMB.galenos.2020.11.078

Objective: This study aims to evaluate the diagnostic value of the De Ritis ratio (DRR) in predicting prostate cancer (PCa) and clinically significant prostate cancer (csPCa) in biopsy-naive patients with suspected PCa. Method: We retrospectively reviewed medical records of 282 male patients who underwent transrectal ultrasound-guided prostate needle biopsy (PNB) between January 2015 and July 2019. Demographic and clinical characteristics of the patients including digital rectal examination findings, preoperative prostate-specific antigene (PSA), aspartate aminotransferase levels, alanine aminotransferase levels, prostate volume, comorbidities and pathological findings of the PNB specimens were noted in detail for each patient. The study cohort was divided into two groups according to the histopathological results of PNB specimens (group 1: patients with benign histopathology, group 2: patients with PCa). The receiver operating characteristic (ROC) curve analysis was conducted to evaluate the diagnostic performance of PSA, PSA density and DRR in predicting PCa. Results: The median age of the participants was 64 (59-69) years. While 71.6% (n=202) of the participants were in group 1, 28.4% (n=80) of them were in group 2. The median DRR value of group 1 was 1.08 (range: 0.89-1.32), and the median DRR value of group 2 was determined as 1.19 (range: 0.95-1.56), and the median DRR value of group 2 was found to be statistically significantly higher than that of group 1 (p=0.013). Statistically significant but a weak positive correlation was observed between PCa in PNB specimens and DRR (r=0.149, p=0.012), while there was no statistically significant correlation between csPCa in PNB specimens and DRR (r=0.002, p=0.983). The ROC curve analysis showed that the cut-off value of DRR for the presence of PCa in PNB specimens was 1.125 and the area under curve was 0.595 (95% confidence interval=0.518-0.672, p=0.013) for the presence of PCa in PNB specimens. Conclusion: This study suggests that DRR had restricted diagnostic importance in predicting PCa in biopsy-naive patients who underwent transrectal PNB.