Effect of Gemfibrozil on The Pharmacokinetics of Selexipag, An oral Prostacyclin Receptor Agonist, And Its Active Metabolite In Healthy Male Subjects

• Published in: Clinical therapeutics Vol. 39; no. 8; pp. e23 - e24
• Main Authors: Bruderer, S., Petersen-Sylla, M., Boehler, M., Remeňová, T., Halabi, A., Dingemanse, J.
• Format: Journal Article
• Language: English
• Published: Bridgewater Elsevier Inc 01.08.2017; Elsevier Limited
• Subjects: Gemfibrozil; Internal Medicine; Medical Education; Pharmacokinetics; Prostacyclin

Methods This was an open-label, randomized, two-treatment, two-period, crossover study including 20 healthy male subjects. In the presence of multiple-dose gemfibrozil, a 2-fold increase in selexipag exposure was observed (geometric mean ratios [Treatment B/Treatment A] and 90% confidence intervals...