Effect of Gemfibrozil on The Pharmacokinetics of Selexipag, An oral Prostacyclin Receptor Agonist, And Its Active Metabolite In Healthy Male Subjects

Methods This was an open-label, randomized, two-treatment, two-period, crossover study including 20 healthy male subjects. In the presence of multiple-dose gemfibrozil, a 2-fold increase in selexipag exposure was observed (geometric mean ratios [Treatment B/Treatment A] and 90% confidence intervals...

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Published inClinical therapeutics Vol. 39; no. 8; pp. e23 - e24
Main Authors Bruderer, S., Petersen-Sylla, M., Boehler, M., Remeňová, T., Halabi, A., Dingemanse, J.
Format Journal Article
LanguageEnglish
Published Bridgewater Elsevier Inc 01.08.2017
Elsevier Limited
Subjects
Gemfibrozil
Internal Medicine
Medical Education
Pharmacokinetics
Prostacyclin
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Summary:Methods This was an open-label, randomized, two-treatment, two-period, crossover study including 20 healthy male subjects. In the presence of multiple-dose gemfibrozil, a 2-fold increase in selexipag exposure was observed (geometric mean ratios [Treatment B/Treatment A] and 90% confidence intervals [CIs] for maximum plasma concentration (Cmax) and area under the plasma...
Bibliography:ObjectType-Article-1
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content type line 14
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.072