A CASE OF PARTIAL D PATIENT WHO FORMED ANTI-D BY BLOOD TRANSFUSION

• Published in: Journal of the Japan Society of Blood Transfusion Vol. 39; no. 4; pp. 766 - 770
• Main Authors: Matsukura, Harumichi, Kimura, Keiko, Yamano, Hajime, Ogawa, Yoshiaki, Okubo, Yasuto, Yamaguchi, Hideo, Tonami, Hirokazu, Takahashi, Masashi, Shioi, Koichi
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Transfusion Medicine and Cell Therapy 1993
• ISSN: 0546-1448; 1883-8383
• DOI: 10.3925/jjtc1958.39.766

A case of partial D patient who formed anti-D by blood transfusion was reported. The patient was a 54-year-old Japanese man suffering from cerebral infarction. His blood group was B, Rho (D) positive and no irregular alloantibodies were detected in pretransfusion screening and crossmaching tests. He received 3 units of ABO-compatible Rho (D) positive concentrated red cells in treatment of anemia due to gastritis on May. 25-27, 1988. Anti-D was found in his serum on Nov. 16, 1989 when he was again hospitalized with sequelae of cerebral infarction. His red cells were shown to react neither with 2 samples of monoclonal anti-D (OSK3 and OSK-1, both of which were prepared by Osaka Red Cross Blood Center) nor 2 samples of commercially purchased monoclonal anti-D. But they did react with 4 samples of polyclonal anti-D by both anti-globulin test and indirect immunof luoresence flow cytometry. His anti-D did not react with D category VI red cells, but reacted with D category IVb and Va cells. The results obtained indicated that he has D category VI red cells and formed anti-D by the transfusion of D-positive red cells.