Cardiac Magnetic Resonance and amyloidosis: Review

Abstract Amyloidosis is a disease caused by extracellular deposition of insoluble protein fibrils, that results in changes in tissue architecture and consequently modification of the organ structure. Cardiac involvement is common in amyloidosis. Two major types of systemic amyloidosis affect the myo...

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Bibliographic Details
Published inInternational Journal of Cardiovascular Sciences Vol. 32; no. 2; pp. 177 - 189
Main Authors Ribeiro, Vaneza Ferreira, Oliveira, Diogo Costa Leandro de, Neves, Daniel Gama das, Nunes, Nágela Simão Vinhosa, Villacorta Junior, Humberto, Nacif, Marcelo Souto
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedade Brasileira de Cardiologia 2019
Subjects
CARDIAC & CARDIOVASCULAR SYSTEMS
Magnetic Resonance Imaging
Plaque, Amyloid/diagnostic imaging
Myocarditis/pathology
Amyloidosis
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Summary:Abstract Amyloidosis is a disease caused by extracellular deposition of insoluble protein fibrils, that results in changes in tissue architecture and consequently modification of the organ structure. Cardiac involvement is common in amyloidosis. Two major types of systemic amyloidosis affect the myocardium - immunoglobulin light chain and transthyretin amyloidosis - each leading to different prognosis. Early detection and diagnosis of cardiac amyloidosis are the main objectives in the assessment of the disease. New techniques of magnetic resonance imaging have minimized the need for biopsies for the diagnosis. Late gadolinium enhancement technique, and more recently T1 mapping, have allowed a simplified evaluation of amyloid deposits and extracellular volume. The aim of this review was to describe basic concepts and updates of the use of magnetic resonance imaging for the diagnosis amyloidosis and evaluation of its severity.
ISSN:2359-4802
2359-5647
2359-5647
DOI:10.5935/2359-4802.20190005