HETEROTOPIC TRANSPLANTATION OF HEART AND THE REGULATORY MECHANISMS OF THE ADAPTATION

Aim. The article describes the results of an experimental study of the adaptation mechanisms of heart and transplant (cardio-pulmonary complex, CPC) in heterotopic transplantation.Materials and methods. CPC`s from recipients (8 dogs) were transplanted in left oblique-diaphragmatic sinus of donor`s (...

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Published inBi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny Vol. 15; no. 3; pp. 5 - 9
Main Authors Baikov, A. N., Tolpekin, V. E., Medvedev, M. A., Semichiev, E. V., Ivanov, S. D.
Format Journal Article
LanguageEnglish
Published Siberian State Medical University (Tomsk) 30.06.2016
Subjects
адаптация сердца
вспомогательное кровообращение
гетеротопическая трансплантация
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Summary:Aim. The article describes the results of an experimental study of the adaptation mechanisms of heart and transplant (cardio-pulmonary complex, CPC) in heterotopic transplantation.Materials and methods. CPC`s from recipients (8 dogs) were transplanted in left oblique-diaphragmatic sinus of donor`s (8 dogs). As a results of parallel connection transplant pre- and post-load of donor`s heart was reduces. Oxygenated blood by CPC was passed the left chambers of donor`s heart and returned to the aorta. Another part from pulmonary artery shunted to the right chamber of CPC as a result decreased systolic pressure on the right ventricle of heart. During the co-working of CPC and heart was happened synchronization.Consequently self-regulating process of circulatory system provides mechanism of adaptation in new conditions. The findings are important for understanding the effectiveness and relevance of this bilogical method of circulatory support.
ISSN:1682-0363
1819-3684
DOI:10.20538/1682-0363-2016-3-5-9