Recent advances in pyrazole synthesis employing diazo compounds and synthetic analogues
Pyrazole is an essential structural component of many pharmaceuticals and agrochemicals. The synthesis of pyrazoles has been a subject of intense research for several decades. Many transformations are now available to conveniently access pyrazoles from readily available starting materials. Conventio...
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| Published in | Organic & biomolecular chemistry Vol. 2; no. 45; pp. 8787 - 8817 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge
Royal Society of Chemistry
23.11.2022
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Pyrazole is an essential structural component of many pharmaceuticals and agrochemicals. The synthesis of pyrazoles has been a subject of intense research for several decades. Many transformations are now available to conveniently access pyrazoles from readily available starting materials. Conventionally, the synthesis of pyrazoles involves the condensation reaction of hydrazines with 1,3-dicarbonyl compounds or their synthetic equivalents and 1,3-dipolar cycloaddition reactions of diazo compounds with dipolarophiles. The present review provides comprehensive information on the development of synthetic approaches to access pyrazoles
via
[3 + 2] cycloaddition reactions of diazo compounds and their synthetic equivalents.
This review summarizes the recent developments in the construction of pyrazoles using diazo compounds, nitrile imines and their synthetic equivalents. |
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| Bibliography: | Sandeep Kumar was born in July 1995 in Gorakhpur, Uttar Pradesh, India. He received his M.Sc. degree in Organic Chemistry in 2018 from Deen Dayal Upadhyaya Gorakhpur University, Uttar Pradesh. He is working as a CSIR-SRF under the supervision of Dr Kishor Mohanan at the Central Drug Research Institute of India, Lucknow. His research interests include the synthesis of various nitrogen containing heterocycles Sanoop P. Chandrasekharan was born in January 1995 in Palakkad, Kerala, India. He completed his B.Sc. degree in 2016 from Government Victoria College, Palakkad. After that, he obtained his M.Sc. degree in Organic Chemistry from Mahatma Gandhi University, Kottayam, in 2018. Presently, he is working as a UGC JRF under the supervision of Dr Kishor Mohanan at the Central Drug Research Institute of India, Lucknow. His research interests include the design and synthesis of medicinally relevant heterocycles using fluorocarbon nucleophiles. Anamika Dhami was born in June 1996 in Pithoragarh, Uttarakhand, India. She received her M.Sc. degree in Organic Chemistry in 2018 from Govind Ballabh Pant University of Agriculture and Technology, Uttarakhand. She is working as a DST-INSPIRE fellow under the supervision of Dr Kishor Mohanan at the Central Drug Research Institute of India, Lucknow. Her research interests gravitate around the exploration of the novel reactivity of diazo compounds. via traceless activation strategies. Kishor Mohanan is a Principal Scientist in the Medicinal and Process Chemistry Division at CSIR-Central Drug Research Institute, Lucknow. He obtained his Ph.D. in chemistry in 2007 under the guidance of Dr Vijay Nair from CSIR-National Institute for Interdisciplinary Science and Technology, Trivandrum. Subsequently, he worked as a post-doctoral fellow in the research groups of Prof. B.-J. Uang at National Tsing Hua University, Taiwan, Prof. Michael Smietana at the University of Montpellier, and Prof. Jean Rodriguez at Aix-Marseille University, France, before joining CSIR-Central Drug Research Institute in 2013 as a Senior Scientist. His current research interest encompasses the development of new reactions involving diazo compounds and fluorocarbon nucleophiles. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 1477-0520 1477-0539 |
| DOI: | 10.1039/d2ob01918c |