Advanced Heart Failure Therapies in Neuromuscular Diseases

• Published in: Current treatment options in cardiovascular medicine Vol. 26; no. 8; pp. 255 - 270
• Main Authors: Agdamag, Arianne Clare, Nandar, Phoo Pwint, Tang, W. H. Wilson
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2024; Springer Nature B.V
• Subjects: Age; Ataxia; Cardiac arrhythmia; Cardiology; Cardiomyopathy; Disease; Electrocardiography; Females; Genetic testing; Heart failure; Kinases; Magnetic resonance imaging; Medical prognosis; Medicine; Medicine & Public Health; Mitochondrial DNA; Mitral valve prolapse; Mortality; Muscular dystrophy; Musculoskeletal system; Neuromuscular diseases; Pathophysiology; Patients; Proteins; Review; Surgery; Topical Collection on Heart Failure; Ultrasonic imaging; Young adults; Heart failure; Left ventricular assist device; Neuromuscular disorders; Arrhythmia; Heart transplant; Cardiomyopathy
• ISSN: 1092-8464; 1534-3189
• DOI: 10.1007/s11936-024-01046-2

Purpose of Review The main objective of this review article is to discuss the prevalence, utilization, and outcomes associated with advanced heart failure therapies among patients with neuromuscular disorders. Recent Findings Neuromuscular disorders often have multisystem involvement with a high prevalence of cardiovascular pathology. With the improvement in management of respiratory related complications, heart failure is now the leading cause of mortality in this patient population. Advanced heart failure therapies with durable left ventricular assist devices and heart transplantation have proven to be feasible and safe treatment options in selected patients. Summary Management of neuromuscular disease involves multidisciplinary team involvement given the systemic nature of the disease. Early recognition and close monitoring of these patients will allow for timely initiation of advanced heart failure therapies that can lead to successful outcomes.