Immunosenescence and Inflamm-Aging: Clinical Interventions and the Potential for Reversal of Aging

Inflammation is often associated with the impairment of the ability to sustain the consequences of the physical, chemical, nutritional, and antigenic triggers of inflammation. The process of immunosenescence may only partially be explained by the senescence of cells, tissues, or the organism, and, h...

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Published inCurēus (Palo Alto, CA) Vol. 16; no. 1; p. e53297
Main Authors Kumar, Samayak J, Shukla, Samarth, Kumar, Sunil, Mishra, Preeti
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 01.01.2024
Subjects
Aging
Antigens
Bone marrow
Cells
Chronic illnesses
Epigenetics
Immune system
Immunology
Inflammation
Kinases
Mitochondrial DNA
Neutrophils
Older people
Oxidative stress
Senescence
Thymus gland
Vaccines
inflamm-aging
pathogenesis
immunosenescence
aging
intervention
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Summary:Inflammation is often associated with the impairment of the ability to sustain the consequences of the physical, chemical, nutritional, and antigenic triggers of inflammation. The process of immunosenescence may only partially be explained by the senescence of cells, tissues, or the organism, and, hence, the hallmarks of immunosenescence may be markedly and differentially affected by the history of an individual's pathogenic encounter. Inflammation is a key component of immunosenescence, which itself is a direct consequence of aging. This review article highlights the therapeutic interventions for slowing the processes of inflamm-aging and immunosenescence and the possible reversal of aging and includes domains of immunomodulatory interventions, vaccination strategies, nutritional interventions, stem cell therapies, personalized medicine, microbiome interventions, and the positive effects of physical activity and exercise.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.53297