Single Dose of Etanercept Injection: A Game Changer in Toxic Epidermal Necrolysis: A Case Series
Toxic Epidermal Necrolysis (TEN) is a rare hypersensitivity reaction to drugs, characterised by widespread erythema, full-thickness epidermal necrosis with mucosal involvement, and extensive apoptosis. It is a dermatological emergency and can be lethal if not promptly treated. The use of steroids in...
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Published in | Journal of clinical and diagnostic research Vol. 17; no. 11; pp. 01 - 04 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
JCDR Research and Publications Private Limited
01.11.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Toxic Epidermal Necrolysis (TEN) is a rare hypersensitivity reaction to drugs, characterised by widespread erythema, full-thickness epidermal necrosis with mucosal involvement, and extensive apoptosis. It is a dermatological emergency and can be lethal if not promptly treated. The use of steroids in managing TEN is controversial since no gold standard therapy exists. However, a single dose of subcutaneous injection of Etanercept (a Tumour Necrosis Factor-alpha (TNF-α) inhibitor) at a dosage of 50 mg has shown promise in preventing mortality and reducing hospital stay. The authors present a case series of six TEN patients, out of which three received a single dose of Etanercept injection. All patients who received Etanercept showed a positive response, achieving complete re-epithelialisation with a median healing time of nine days. In conclusion, injection of Etanercept, a TNF-α inhibitor, effectively inhibits Fas-Fas ligand activation, thus preventing apoptosis and extensive necrosis. |
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ISSN: | 2249-782X 0973-709X |
DOI: | 10.7860/JCDR/2023/62912.18615 |