A novel small-cell lung carcinoma-specific DNA-binding activity related to the transcription factor ap-1

A novel TRE-binding protein complex was detected specifically in 12 out of 13 small cell lung carcinoma (SCLC) cell lines. This complex was characterised by a lower electrophoretic mobility than the 'ubiquitous' complex present in all other carcinoma cell lines analysed. As shown by UV-cro...

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Bibliographic Details
Published inInternational journal of oncology Vol. 2; no. 4; p. 503
Main Authors Adamkiewicz, J, Behn, M, Brusselbach, S, Havemann, K, Muller, R
Format Journal Article
LanguageEnglish
Published Greece 01.04.1993
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Summary:A novel TRE-binding protein complex was detected specifically in 12 out of 13 small cell lung carcinoma (SCLC) cell lines. This complex was characterised by a lower electrophoretic mobility than the 'ubiquitous' complex present in all other carcinoma cell lines analysed. As shown by UV-crosslinking and South-Western blotting, the SCLC-specific complex contains a protein with an apparent M(r) > 100 kD, which is far bigger than all Fos and Jun proteins described to date. In addition, the DNA-binding specificity of this complex is different from the specificity of the 'ubiquitous' complex or a Fos/Jun heterodimer.
ISSN:1019-6439
DOI:10.3892/ijo.2.4.503