Bullous Pemphigoid in a Centenarian Male Simulating Toxic Epidermal Necrolysis

Bullous pemphigoid (BP) is one of the most common autoimmune blistering diseases and classically presents as large, tense bullae. We report a case of BP with toxic epidermal necrolysis (TEN)-like manifestations in a 103-year-old male, the oldest known patient to present with an acute onset of BP. Ou...

Full description

Saved in:
Bibliographic Details
Published inCurēus (Palo Alto, CA) Vol. 15; no. 9
Main Authors Shakhashiro, Muna, Bradley, Taylor R, Tobin, Stuart
Format Journal Article
LanguageEnglish
Published Palo Alto Cureus Inc 11.09.2023
Cureus
Subjects
Antibodies
Biopsy
Case reports
Dermatology
Medical diagnosis
Older people
Skin
United States > US
Online AccessGet full text

Cover

More Information
Summary:Bullous pemphigoid (BP) is one of the most common autoimmune blistering diseases and classically presents as large, tense bullae. We report a case of BP with toxic epidermal necrolysis (TEN)-like manifestations in a 103-year-old male, the oldest known patient to present with an acute onset of BP. Our patient presented with extensive erosive lesions comprising 12% of the total body surface area, raising suspicion of TEN and Staphylococcal scalded skin syndrome. Detailed clinical, histological, and immunofluorescence analyses were performed, confirming a diagnosis of BP. Atypical presentations of blistering disorders can be a diagnostic challenge and require the use of histologic and direct immunofluorescence testing to distinguish between clinically similar cutaneous diseases. Proper diagnosis is essential to ensure appropriate management and patient care.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.45037