Aqueous extract of Aloe vera ameliorates ethanol-ınduced liver damage and oxidative stress in Balb/c mice

Exessive alcohol abuse is associated with physiological and pathological effects on the body. Aloe vera was selected because of its many beneficial qualities. 25 mice were given the following treatment protocol: distilled water (normal control), 20% ethanol at 10ml/kg (negative control), 25mg/kg Aqu...

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Published inJournal of Research in Pharmacy Vol. 29; no. 2; pp. 552 - 560
Main Authors Saleh, Jilmari Shadrach, Ishaya, Helga, Chiroma, Samaila Musa, Attah, Martha Orendu Oche, Manye, Sunday Joseph, Dibal, Nathan Isaac
Format Journal Article
LanguageEnglish
Published 04.08.2025
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Summary:Exessive alcohol abuse is associated with physiological and pathological effects on the body. Aloe vera was selected because of its many beneficial qualities. 25 mice were given the following treatment protocol: distilled water (normal control), 20% ethanol at 10ml/kg (negative control), 25mg/kg Aqueous extract of Aloe vera (AA) plus 20% ethanol, 50mg/kg AA plus 20% ethanol and 100mg/kg silymarin plus 20% ethanol (positive control) respectively daily for 18 days. After sacrifice, blood was collected for biochemical analysis. The liver was analysed histologically, histochemically and part was macerated to determine oxidative stress biomarkers. AA significantly decreased (P< .05) AST activity but it did not significantly decrease ALT activity.It significantly increased (P
ISSN:2630-6344
2630-6344
DOI:10.12991/jrespharm.1662053