Plasma beta-2-microglobulin and fibronectin levels in beta-thalassaemia

The plasma beta 2-microglobulin (beta 2-MG) levels in 118 children with thalassaemia were investigated. The mean level was higher than in healthy children. A significant increase of beta 2-MG was associated with hypersplenism (3.14 +/- 0.6 mg/l). The beta 2-MG levels appeared to reflect reticuloendo...

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Bibliographic Details
Published inActa haematologica Vol. 71; no. 4; p. 257
Main Authors Cooper, E H, Forbes, M A, Bowen, M, Gabutti, V, Piga, A
Format Journal Article
LanguageEnglish
Published Switzerland 1984
Subjects
Adolescent
Age Factors
beta 2-Microglobulin - analysis
Child
Child, Preschool
Fibronectins - blood
Heterozygote
Humans
Hypersplenism - metabolism
Infant
Splenectomy
Thalassemia - blood
Thalassemia - genetics
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Summary:The plasma beta 2-microglobulin (beta 2-MG) levels in 118 children with thalassaemia were investigated. The mean level was higher than in healthy children. A significant increase of beta 2-MG was associated with hypersplenism (3.14 +/- 0.6 mg/l). The beta 2-MG levels appeared to reflect reticuloendothelial system activity but were not related to iron overload. Fibronectin levels were generally lower than in healthy adults; profound chronic fibronectin depletion was not accompanied by an increased liability to infection.
ISSN:0001-5792
1421-9662
DOI:10.1159/000206597