Core‐Shell Structured hybrid with Photo‐triggered Antibacterial activity for Enhancing Skin Regeneration

• Published in: ChemistrySelect (Weinheim) Vol. 8; no. 28
• Main Authors: Zhang, Bin, Gao, Feng, Li, Xiaotong, Yuan, Jingsong, Bian, Weiwei, Zhai, Xiaofei, Chu, Lichao, Zhao, Chunzhen, Zhou, Baolong
• Format: Journal Article
• Language: English
• Published: 26.07.2023
• Subjects: Antibacterial; Hybrid; Por-CMP; Skin Regeneration; ZIF-8
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.202301166

Open wounds infected by bacteria are gearing increasing attention whose treatment are complicated by the appearance of multidrug‐resistant bacteria. Photothermal therapy, kill bacteria through the photothermal conversion, has been extensively studied. Whereas, the high cost and low yield of the active ingredients have limited its widespread use. To address this challenge, the template assisted coating strategy was adopted to prepare a biocompatible photothermal agent, where the hybrid was prepared via in situ copolymerization of 5,10,15,20‐tetrakis(4‐ethynylphenyl)‐21H,23H‐porphine (Por) on the surface of ZIF‐8 template. The introduction of ZIF‐8 in the inner of the hybrid, could not only lower the cost of photosensitizer (i. e., the porphyrin), but also maintain the activity of photosensitizer (PS) finely, which could be used directly as the antimicrobial dressing. In vitro experiments validated the as‐prepared hybrid presents high‐efficiency PTT antibacterial activity. Meanwhile, in vivo chronic wound‐healing experiments on mice verified the as‐synthesized hybrid also delivers excellent anti‐infection and tissue remodeling activities. This work highlights the potential of low‐cost hybrid‐based multifunctional biomaterials in the treatment of skin injuries in clinical settings. Herein, a facile surface coating method was adopted to develop low cost hybrid with typical core‐shell structure, which could be used as a high‐efficiency broad‐spectrum antimicrobial agent with photo‐triggered bactericidal effect. The hybrid was prepared using ZIF‐8 as the template and the porphyrin‐based polymer was acted as the photoactive coating.