Effect of Moxibustion Therapy on the Serumal Intercellular Cell Adhesion Molecule and the Histopathology of Experimental Arthritis in Rats
目的：观察艾灸肾俞、足三里穴对类风湿关节炎模型大鼠血清细胞粘附分子（intercellular cell adhesion molecule-1, ICAM-1 ）及病理组织的影响，探讨艾灸温通效应的作用机制。方法：建立类风湿关节炎大鼠模型。艾灸模型大鼠肾俞、足三里穴，分析比较大鼠的后肢踝关节病理切片的变化及运用酶联免疫吸附法（ELISA法）检测血清细胞粘附分子（ICAM-1）的含量。结果：模型大鼠与正常组比较，跖围明显肿胀（P〈0．01），滑膜层数增加，软骨受炎细胞侵蚀，血清ICAM-1的含量明显升高。艾灸治疗后跖围明显减小（P〈0．01），滑膜层数有减少的趋势，关节软骨未见病理性损伤，血清...
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| Published in | Journal of acupuncture and tuina science Vol. 8; no. 4; pp. 210 - 213 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
Shanghai Research Institute of Acupuncture and Meridian
01.08.2010
Springer Nature B.V Research Institute of Acupuncture and Meridian, Anhui College of Traditional Chinese Medicine, Hefei 230038, P. R. China |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-3597 1993-0399 |
| DOI | 10.1007/s11726-010-0410-3 |
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| Abstract | 目的：观察艾灸肾俞、足三里穴对类风湿关节炎模型大鼠血清细胞粘附分子（intercellular cell adhesion molecule-1, ICAM-1 ）及病理组织的影响，探讨艾灸温通效应的作用机制。方法：建立类风湿关节炎大鼠模型。艾灸模型大鼠肾俞、足三里穴，分析比较大鼠的后肢踝关节病理切片的变化及运用酶联免疫吸附法（ELISA法）检测血清细胞粘附分子（ICAM-1）的含量。结果：模型大鼠与正常组比较，跖围明显肿胀（P〈0．01），滑膜层数增加，软骨受炎细胞侵蚀，血清ICAM-1的含量明显升高。艾灸治疗后跖围明显减小（P〈0．01），滑膜层数有减少的趋势，关节软骨未见病理性损伤，血清ICAM—1的含量下降，与模型组比较差异显著（P〈0．01）结论：艾灸具有抑制大鼠病变关节滑膜炎症与增生，改善炎性细胞对软骨的侵蚀，预防关节骨膜病变，延缓病理进程的作用；艾灸能抑制血清细胞粘附分子ICAM—1的产生，阻抑血管翳生成，可能是艾灸温经通络治疗实验性关节炎的作用机制之一。 |
|---|---|
| AbstractList | R2-03; 目的:观察艾灸肾俞、足三里穴对类风湿关节炎模型大鼠血清细胞粘附分子 (intercellular cell adhesion molecule-1,ICAM-1)及病理组织的影响,探讨艾灸温通效应的作 用机制.方法:建立类风湿关节炎大鼠模型.艾灸模型大鼠肾俞、足三里穴,分析比较大鼠的 后肢踝关节病理切片的变化及运用酶联免疫吸附法(ELISA法)检测血清细胞粘附分子 (ICAM-1)的含量.结果:模型大鼠与正常组比较,跖围明显肿胀(P<0.01),滑膜层数增 加,软骨受炎细胞侵蚀,血清ICAM-1 的含量明显升高.艾灸治疗后跖围明显减小(P<0.01), 滑膜层数有减少的趋势,关节软骨未见病理性损伤,血清ICAM-1 的含量下降,与模型组比较 差异显著(P<0.01).结论:艾灸具有抑制大鼠病变关节滑膜炎症与增生,改善炎性细胞对软 骨的侵蚀,预防关节骨膜病变,延缓病理进程的作用;艾灸能抑制血清细胞粘附分子ICAM-1 的产生,阻抑血管翳生成,可能是艾灸温经通络治疗实验性关节炎的作用机制之一. ObjectiveTo observe the effects of moxibustion therapy at Shenshu (BL 23) and Zusanli (ST 36) of rats with induced rheumatoid arthritis (RA) on the serumal intercellular cell adhesion molecule-1 (ICMA-1) and the pathological tissue, to discuss the mechanism of the warming and activating effect of moxibustion.MethodsAfter establishing the RA rats model, the induced rats were treated with moxibustion therapy on the acupoint Shenshu (BL 23) and Zusanli (ST 36), followed by analyzing the pathological section of the ankle of the hind limb and testing the ICAM-1 content with ELISA.ResultsThe plantar circumferences of the induced rat increased significantly compared with the rats in the control group (P<0.01), accompanying with the increase of the synovial layer, the erosion of phlogocytes to chondrocytes and the specific increase of ICAM-1 content. After the moxibustion therapy, the plantar circumferences decreased significantly (P<0.01) while the synovial layer tended to reduce. In addition, there was no pathological damage of the articular cartilage and the ICAM content decreased with significant deviation (P<0.01), compared to the model group.ConclusionIt was concluded that moxibustion therapy could inhibit the arthrosynovitis and hyperplasia, ameliorate the erosion of phlogocyte to cartilage, prevent articular periosteal lesions and delay the pathological course. The warming and activating effect of moxibustion therapy may involve the inhibition of the formation of ICAM-1 and pannus. 目的：观察艾灸肾俞、足三里穴对类风湿关节炎模型大鼠血清细胞粘附分子（intercellular cell adhesion molecule-1, ICAM-1 ）及病理组织的影响，探讨艾灸温通效应的作用机制。方法：建立类风湿关节炎大鼠模型。艾灸模型大鼠肾俞、足三里穴，分析比较大鼠的后肢踝关节病理切片的变化及运用酶联免疫吸附法（ELISA法）检测血清细胞粘附分子（ICAM-1）的含量。结果：模型大鼠与正常组比较，跖围明显肿胀（P〈0．01），滑膜层数增加，软骨受炎细胞侵蚀，血清ICAM-1的含量明显升高。艾灸治疗后跖围明显减小（P〈0．01），滑膜层数有减少的趋势，关节软骨未见病理性损伤，血清ICAM—1的含量下降，与模型组比较差异显著（P〈0．01）结论：艾灸具有抑制大鼠病变关节滑膜炎症与增生，改善炎性细胞对软骨的侵蚀，预防关节骨膜病变，延缓病理进程的作用；艾灸能抑制血清细胞粘附分子ICAM—1的产生，阻抑血管翳生成，可能是艾灸温经通络治疗实验性关节炎的作用机制之一。 Objective To observe the effects of moxibustion therapy at Shenshu (BL 23) and Zusanli (ST 36) of rats with induced rheumatoid arthritis (RA) on the serumal intercellular cell adhesion molecule-1 (ICMA-1) and the pathological tissue, to discuss the mechanism of the warming and activating effect of moxibustion. Methods After establishing the RA rats model, the induced rats were treated with moxibustion therapy on the acupoint Shenshu (BL 23) and Zusanli (ST 36), followed by analyzing the pathological section of the ankle of the hind limb and testing the ICAM-1 content with ELISA. Results The plantar circumferences of the induced rat increased significantly compared with the rats in the control group ( P <0.01), accompanying with the increase of the synovial layer, the erosion of phlogocytes to chondrocytes and the specific increase of ICAM-1 content. After the moxibustion therapy, the plantar circumferences decreased significantly ( P <0.01) while the synovial layer tended to reduce. In addition, there was no pathological damage of the articular cartilage and the ICAM content decreased with significant deviation ( P <0.01), compared to the model group. Conclusion It was concluded that moxibustion therapy could inhibit the arthrosynovitis and hyperplasia, ameliorate the erosion of phlogocyte to cartilage, prevent articular periosteal lesions and delay the pathological course. The warming and activating effect of moxibustion therapy may involve the inhibition of the formation of ICAM-1 and pannus. |
| Abstract_FL | Objective: To observe the effects of moxibustion therapy at Shenshu (BL 23) and Zusanli (ST 36) of rats with induced rheumatoid arthritis (RA) on the serumal intercellular cell adhesion molecule-1 (ICMA-1) and the pathological tissue, to discuss the mechanism of the warming and activating effect of moxibustion. Methods: After establishing the RA rats model, the induced rats were treated with moxibustion therapy on the acupoint Shenshu (BL 23) and Zusanli (ST 36), followed by analyzing the pathological section of the ankle of the hind limb and testing the ICAM-1 content with ELISA. Results: The plantar circumferences of the induced rat increased significantly compared with the rats in the control group (P<0.01), accompanying with the increase of the synovial layer, the erosion of phlogocytes to chondrocytes and the specific increase of ICAM-1 content. After the moxibustion therapy, the plantar circumferences decreased significantly (P<0.01) while the synovial layer tended to reduce. In addition, there was no pathological damage of the articular cartilage and the ICAM content decreased with significant deviation (P<0.01), compared to the model group. Conclusion: It was concluded that moxibustion therapy could inhibit the arthrosynovitis and hyperplasia, ameliorate the erosion of phlogocyte to cartilage, prevent articular periosteal lesions and delay the pathological course. The warming and activating effect of moxibustion therapy may involve the inhibition of the formation of ICAM-1 and pannus. |
| Author | 何璐 Lars Dirckinck-Holmfeld 蔡荣林 宋小鸽 胡玲 余爽 张道琴 |
| AuthorAffiliation | Research Institute of Acupuncture and Meridian, Anhui College of Traditional Chinese Medicine, Hefei 230038, E R. China |
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| Cites_doi | 10.1016/0167-5699(93)90267-O 10.1161/01.STR.30.2.321 |
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| Copyright | Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag Berlin Heidelberg 2010 Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag Berlin Heidelberg 2010. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| Keywords | Rheumatoid 大鼠 灸法 细胞间粘附分子-1 Rats Intercellular Adhesion Molecule-1 Arthritis 类风湿 R2-03 关节炎 Moxibustion Therapy 关节炎,类风湿 Arthritis,Rheumatoid |
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| PublicationTitle | Journal of acupuncture and tuina science |
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| References_xml | – volume: 6 start-page: 6 issue: 1 year: 1998 end-page: 11 ident: CR2 article-title: Pathological Study of Animal Model of Wind-colddampness Bi and Wind-dampness-heat Bi-impediment Syndrome in Rheumatoid Arthritis publication-title: Chinese Journal of Experimental Animal – volume: 4 start-page: 108 issue: 2 year: 2006 end-page: 109 ident: CR6 article-title: Relationship between Traditional Chinese Medicine Syndrome Intercellular Cell Adhesion Molecule-1 in Coronary Heart Disease publication-title: Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease – volume: 22 start-page: 14 issue: 1 year: 2003 end-page: 16 ident: CR1 article-title: Influence of Small-cone Moxibustion on the Cellular Immunity in Adjuvant Arthritis Rats publication-title: Shanghai J Acu-mox – volume: 21 start-page: 1034 issue: 7 year: 2003 ident: CR11 article-title: Effects of Moxibustion on HSP70 in Experimental RA Rats publication-title: Chinese Archives of Traditional Chinese Medicine – volume: 25 start-page: 1745 issue: 8 year: 2007 ident: CR3 article-title: On RA Experimental Model Integrates Disease and Syndrome publication-title: Chinese Archives of Traditional Chinese Medicine – volume: 14 start-page: 506 issue: 10 year: 1993 end-page: 512 ident: CR4 article-title: Circulating Adhesion Molecules in Disease publication-title: Immunol Today doi: 10.1016/0167-5699(93)90267-O – volume: 26 start-page: 29 issue: 2 year: 2003 ident: CR10 article-title: Changes of Joint Swelling and Expression of Caspase-3 of Experimental Rheumatoid Arthristis Rat after Small-cone Moxibustion publication-title: Journal of Chengdu University of Traditional Chinese Medicine – volume: 30 start-page: 321 issue: 2 year: 1999 end-page: 327 ident: CR5 article-title: Intrathecal Expression of Proteins Regulating Apoptosis in Acute Stroke publication-title: Stroke – volume: 24 start-page: 10 issue: 2 year: 2007 ident: CR7 article-title: Research Progress of Intercellular Cell Adhesion Molecule and Chronic Heart Failure publication-title: Information of Traditional Chinese Medicine – volume: 64 start-page: 313 issue: 3 year: 1991 end-page: 320 ident: CR8 article-title: Immunolocalization of Endothelial and Leukocyte Adhesion Molecules in Human Rheumatoid and Osteoarthritic Synovial Tissues publication-title: Lab Invest – volume: 9 start-page: 57 issue: 2 year: 2003 ident: CR9 article-title: Effects of Moxibustion on Hypothalamic-pituitary-adrenal Cortex Axis in the Rheumatoid Arthritis Rats publication-title: China Journal of Basic Medicine in Traditional Chinese Medicine – volume: 24 start-page: 10 issue: 2 year: 2007 ident: 410_CR7 publication-title: Information of Traditional Chinese Medicine – volume: 30 start-page: 321 issue: 2 year: 1999 ident: 410_CR5 publication-title: Stroke doi: 10.1161/01.STR.30.2.321 – volume: 9 start-page: 57 issue: 2 year: 2003 ident: 410_CR9 publication-title: China Journal of Basic Medicine in Traditional Chinese Medicine – volume: 22 start-page: 14 issue: 1 year: 2003 ident: 410_CR1 publication-title: Shanghai J Acu-mox – volume: 21 start-page: 1034 issue: 7 year: 2003 ident: 410_CR11 publication-title: Chinese Archives of Traditional Chinese Medicine – volume: 64 start-page: 313 issue: 3 year: 1991 ident: 410_CR8 publication-title: Lab Invest – volume: 6 start-page: 6 issue: 1 year: 1998 ident: 410_CR2 publication-title: Chinese Journal of Experimental Animal – volume: 4 start-page: 108 issue: 2 year: 2006 ident: 410_CR6 publication-title: Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease – volume: 26 start-page: 29 issue: 2 year: 2003 ident: 410_CR10 publication-title: Journal of Chengdu University of Traditional Chinese Medicine – volume: 25 start-page: 1745 issue: 8 year: 2007 ident: 410_CR3 publication-title: Chinese Archives of Traditional Chinese Medicine – volume: 14 start-page: 506 issue: 10 year: 1993 ident: 410_CR4 publication-title: Immunol Today doi: 10.1016/0167-5699(93)90267-O |
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| Snippet | 目的：观察艾灸肾俞、足三里穴对类风湿关节炎模型大鼠血清细胞粘附分子（intercellular cell adhesion molecule-1, ICAM-1... Objective To observe the effects of moxibustion therapy at Shenshu (BL 23) and Zusanli (ST 36) of rats with induced rheumatoid arthritis (RA) on the serumal... ObjectiveTo observe the effects of moxibustion therapy at Shenshu (BL 23) and Zusanli (ST 36) of rats with induced rheumatoid arthritis (RA) on the serumal... R2-03; 目的:观察艾灸肾俞、足三里穴对类风湿关节炎模型大鼠血清细胞粘附分子 (intercellular cell adhesion molecule-1,ICAM-1)及病理组织的影响,探讨艾灸温通效应的作 用机制.方法:建立类风湿关节炎大鼠模型.艾灸模型大鼠肾俞、足三里穴,分析比较大鼠的... |
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| SubjectTerms | Acupuncture Arthritis Cartilage Cell adhesion & migration Medicine Medicine & Public Health Special Topic for 973 Program 关节炎 类风湿 细胞间粘附分子-1 |
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| Title | Effect of Moxibustion Therapy on the Serumal Intercellular Cell Adhesion Molecule and the Histopathology of Experimental Arthritis in Rats |
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