Amperometric sandwich‐type aptasensor based on peroxidase mimetic Au@Pt for the carcinoembryonic antigen

For sensitive analysis of cancer biomarker carcinoembryonic antigen (CEA), an amperometric sandwich‐type aptasensor is proposed based on a signal amplification strategy of Au@Pt bimetallic nanoprobes. As the excellent catalytic activity to hydrogen peroxide (H2O2), core‐shell Au@Pt nanoparticles are...

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Bibliographic Details
Published inElectroanalysis (New York, N.Y.) Vol. 35; no. 5
Main Authors Li, Hui, Zhang, Yuting, Chang, Anqi, Cai, Shixin, Zhou, Nandi
Format Journal Article
LanguageEnglish
Published 01.05.2023
Subjects
cancer biomarker
core-shell Au@Pt
electrochemical aptasensor
nanoprobe
sandwich-type
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Summary:For sensitive analysis of cancer biomarker carcinoembryonic antigen (CEA), an amperometric sandwich‐type aptasensor is proposed based on a signal amplification strategy of Au@Pt bimetallic nanoprobes. As the excellent catalytic activity to hydrogen peroxide (H2O2), core‐shell Au@Pt nanoparticles are employed as nanoprobes by conjugating directly with the secondary aptamer of CEA (Apt‐II). Due to the synergic recognition effect of dual aptamers and the excellent catalytic activity of nanoprobes, this amperometric sandwich‐type aptasensor for CEA exhibits high specificity and good sensitivity with a limit of detection of 0.31 ng/mL, along with a wide linear range from 0.1 ng/mL to 100 ng/mL.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.202200443