Clinical assessment of therapeutic effects on cancer using 18F-2-fluoro-2-deoxy-D-glucose and positron emission tomography : preliminary study of lung cancer

Using positron emission tomography, we studied the tumor uptake of 18F-2-fluoro-2-deoxy-D-glucose (18FDG) in five lung cancer patients before and after anti-cancer therapy (radiotherapy and/or chemotherapy). The tumor uptake of 18FDG was classified as positive and negative; the former, by increasing...

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Published inInternational journal of radiation oncology, biology, physics Vol. 19; no. 4; pp. 1005 - 1010
Main Authors ABE, Y, MATSUZAWA, T, HATAZAWA, J, TADA, M, IDO, T, WATANUKI, S, FUJIWARA, T, ITOH, M, FUKUDA, H, YAMAGUCHI, K, KUBOTA, K, HATAZAWA, H, YMAGUCHI, K
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier 01.10.1990
Subjects
Adult
Aged
Biological and medical sciences
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - therapy
Carcinoma, Small Cell - metabolism
Carcinoma, Small Cell - therapy
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - therapy
Deoxyglucose - analogs & derivatives
Deoxyglucose - pharmacokinetics
Fluorine Radioisotopes
Fluorodeoxyglucose F18
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lung Neoplasms - metabolism
Lung Neoplasms - therapy
Male
Medical sciences
Middle Aged
Prognosis
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Respiratory system
Tomography, Emission-Computed
Human
Tomography
Tumor
Treatment
Respiratory disease
Lung
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Summary:Using positron emission tomography, we studied the tumor uptake of 18F-2-fluoro-2-deoxy-D-glucose (18FDG) in five lung cancer patients before and after anti-cancer therapy (radiotherapy and/or chemotherapy). The tumor uptake of 18FDG was classified as positive and negative; the former, by increasing the uptake of 18FDG with time, and the latter, by decreasing or the constant uptake of 18FDG. Before therapy, all cases tested positive. After therapy, three cases were negative and two cases remained positive. All negative cases corresponded to complete second 18FDG study. Our findings in the 18FDG study correlate with the clinical results. 18FDG is a promising method for assessing therapeutic effects on cancer clinically.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0360-3016
1879-355X
DOI:10.1016/0360-3016(90)90026-g