The effects of antiasthmatic drugs against immune complex-induced bronchoconstriction in anesthetized dogs

• Published in: Pharmacology Vol. 18; no. 6; p. 311
• Main Author: Mielens, Z E
• Format: Journal Article
• Language: English
• Published: Switzerland 1979
• Subjects: Aminophylline - therapeutic use; Animals; Antigen-Antibody Complex; Atropine - therapeutic use; Bronchial Spasm - chemically induced; Bronchial Spasm - drug therapy; Bronchial Spasm - etiology; Bronchodilator Agents - therapeutic use; Carbachol; Carbazoles - therapeutic use; Cromolyn Sodium - therapeutic use; Dogs; Drug Evaluation, Preclinical; Ethanolamines - therapeutic use; Ethylenediamines - therapeutic use; Histamine; Isoproterenol - therapeutic use; Prednisone - therapeutic use; Pyridines - therapeutic use
• ISSN: 0031-7012
• DOI: 10.1159/000137271

Bronchoconstriction was induced in nonsensitized dogs by intravenous injections of soluble immune complexes. Immune complex-induced bronchoconstriction was associated with a drop in blood pressure and a drop in the circulating complement levels. Different antiasthmatic agents were compared for their effects in dogs against bronchoconstriction induced by intravenous injections of immune complexes or histamone. Bronchodilators (isoproterenol, aminophylline, and bitolterol) inhibited both types of bronchoconstriction, whereas disodium cromoglycate, prednisone, and oxarbazole inhibited only bronchoconstriction induced by immune complexes. Thenyldiamine and atropine inhibited histamine- and carbachol-induced bronchoconstriction, respectively, but they were ineffective at the same doses against immune complex-induced bronchoconstriction.