Selective inhibition of type A monoamine oxidase by pyrazidol

Effect of a new antidepressant pyrazidol (1,10-trimethylene-8-methyl-1,2,3,4-tetrahydropyrazino /1,2-/ indole) on the liver and brain MAO activity of rats was studied in experiments in vivo and in vitro. Pyrazidol selectively blocks type A MAO (the substrates serotonin and noradrenaline) and does no...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 91; no. 2; p. 169
Main Authors Mashkovskiĭ, M D, Gorkin, V Z, Verevkina, I V, Asnina, V V, Tupikina, S M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.02.1981
Subjects
Animals
Brain - enzymology
Carbazoles - pharmacology
Deamination
Dopamine - metabolism
In Vitro Techniques
Isoenzymes - antagonists & inhibitors
Male
Mitochondria, Liver - enzymology
Monoamine Oxidase Inhibitors
Norepinephrine - metabolism
Phenethylamines - metabolism
Rats
Serotonin - metabolism
Substrate Specificity
Tyramine - metabolism
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Summary:Effect of a new antidepressant pyrazidol (1,10-trimethylene-8-methyl-1,2,3,4-tetrahydropyrazino /1,2-/ indole) on the liver and brain MAO activity of rats was studied in experiments in vivo and in vitro. Pyrazidol selectively blocks type A MAO (the substrates serotonin and noradrenaline) and does not virtually affect or has a far less action on type B MAO (the substrate 2-phenylethylamine).
ISSN:0365-9615
DOI:10.1007/BF00835392