Acute Hemorrhagic Leucoencephalitis (AHLE): A Rare CNS Presentation of Mycoplasma pneumoniae

Acute hemorrhagic leucoencephalitis (AHLE) is a rare inflammatory disease of the brain. Literature on the presentation and management of this rare disease is limited. A Mycoplasma pneumoniae infection is considered a possible trigger for acute hemorrhagic leucoencephalitis (Weston-Hurst syndrome). W...

Full description

Saved in:
Bibliographic Details
Published inCurēus (Palo Alto, CA) Vol. 14; no. 10
Main Authors Been Sayeed, S.K. Jakaria, Moniruzzaman, Md, Mahmud, Reaz, Rashid, Mohammad B, Chandra Das, Subir
Format Journal Article
LanguageEnglish
Published Palo Alto Cureus Inc 31.10.2022
Cureus
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Acute hemorrhagic leucoencephalitis (AHLE) is a rare inflammatory disease of the brain. Literature on the presentation and management of this rare disease is limited. A Mycoplasma pneumoniae infection is considered a possible trigger for acute hemorrhagic leucoencephalitis (Weston-Hurst syndrome). We report a case of a 58-year-old man presenting with an altered level of consciousness following a history of acute respiratory tract infection. He had also clinical and laboratory features of disseminated intravascular coagulation (DIC). Brain imaging was suggestive of hemorrhagic encephalitis involving both the fronto-temporo-parieto-occipital lobes involving the cortical, subcortical, and splenium of the corpus callosum and the posterior limb of the right internal capsule. Antibodies against Mycoplasma were strongly positive in serum. The patient was treated with fresh frozen plasma, broad-spectrum antibiotics, and methylprednisolone. However, the patient died after 17 days of hospitalization probably due to multiorgan failure and brain herniation.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.30921