Tip-Variant Focal Segmental Glomerulosclerosis in a Patient With Primary Hypothyroidism: A Case Report

Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome (NS) and one of the leading causes of end-stage kidney disease. Endocrinological abnormalities due to the urinary loss of hormone-binding proteins, such as transient hypothyroidism, are well documented in FSGS. Seconda...

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Published inCurēus (Palo Alto, CA) Vol. 14; no. 10
Main Authors CA, Jayashankar, LR, Pavan, Ishaq, Mohammed, S, Pruthvi R, Joshi, Amey
Format Journal Article
LanguageEnglish
Published Palo Alto Cureus Inc 07.10.2022
Cureus
Subjects
Allergy/Immunology
Antibodies
Biopsy
Case reports
Cholesterol
Creatinine
Cytomegalovirus
Edema
Enzymes
Hemoglobin
Hepatitis B
Hepatitis C
HIV
Human immunodeficiency virus
Hypothyroidism
Immune system
Internal Medicine
Kidney diseases
Kidneys
Kinases
Laboratories
Lipoproteins
Microscopy
Mutation
Nephrology
Patients
Permeability
Proteins
Severe acute respiratory syndrome coronavirus 2
Thyroid gland
Urine
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Summary:Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome (NS) and one of the leading causes of end-stage kidney disease. Endocrinological abnormalities due to the urinary loss of hormone-binding proteins, such as transient hypothyroidism, are well documented in FSGS. Secondary FSGS can arise due to viral infections, drugs, and pre-existing glomerular diseases. Few reports have highlighted the occurrence of FSGS in the background of hypothyroidism. We present a case of a young male with primary hypothyroidism who developed the tip variant of FSGS. A combination of oral corticosteroids and angiotensin-converting enzyme (ACE) inhibitors was successful in causing remission of the FSGS with no relapse.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.30020