Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Subtype of the Thyroid

Non-Hodgkin lymphoma is one of the most common hematological malignancies having both nodal and extranodal sites of involvement. The thyroid gland is one of the rarest primary sites. Most cases of primary thyroid lymphoma are diffuse large B-cell in nature; thus, aggressive and in extreme cases can...

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Bibliographic Details
Published inCurēus (Palo Alto, CA) Vol. 13; no. 10
Main Authors Waqar, Syed Hamza Bin, Khan, Anosh Aslam, Coca Guzman, Juan, Gottesman, Susan RS, McFarlane, Isabel
Format Journal Article
LanguageEnglish
Published Palo Alto Cureus Inc 19.10.2021
Cureus
Subjects
Airway management
Biopsy
Bone marrow
Case reports
Dysphagia
Endocrinology/Diabetes/Metabolism
Flow cytometry
Gene expression
Hematology
Hypothyroidism
Lymphocytes
Lymphoma
Oncology
Radiation therapy
Stains & staining
Surgery
Surveillance
Thyroid gland
Tomography
Ultrasonic imaging
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Summary:Non-Hodgkin lymphoma is one of the most common hematological malignancies having both nodal and extranodal sites of involvement. The thyroid gland is one of the rarest primary sites. Most cases of primary thyroid lymphoma are diffuse large B-cell in nature; thus, aggressive and in extreme cases can rapidly lead to airway compromise, especially in patients who have been living with goiter for years. We present one such case of a 64-year-old female who presented with signs of airway compromise, requiring emergent airway intubation and surgical debulking. She was treated with emergent chemotherapy (DA-EPOCH-R regimen), without radiotherapy and this resulted in complete remission.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.18893