Reaction between 5-isopropylidene-2,2-dimethyl-1,3-dioxane-4,6-dione and tert-butyl isocyanide in the presence of primary or secondary amines

5-Isopropylidene-2,2-dimethyl-1,3-dioxane-4,6-dione (the condensation product of Meldrum's acid and acetone) reacts smoothly with tert-butyl isocyanide in the presence of primary or secondary amines to produce N-tert-butyl-2,2-dimethylbutyramide derivatives and/or 1-tert-butyl-4,4-dimethyl-2,5-...

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Bibliographic Details
Published inMonatshefte für Chemie Vol. 134; no. 12; pp. 1651 - 1658
Main Authors Yavari, Habibi, A, Hosseini-Tabatabaei, MR, Bijanzadeh, HR
Format Journal Article
LanguageEnglish
Published WIEN Springer Nature 01.12.2003
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
MELDRUMS ACID
alkyl isocyanides
Ugi reaction
Meldrum's acid
triamides
amidosuccinimides
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Summary:5-Isopropylidene-2,2-dimethyl-1,3-dioxane-4,6-dione (the condensation product of Meldrum's acid and acetone) reacts smoothly with tert-butyl isocyanide in the presence of primary or secondary amines to produce N-tert-butyl-2,2-dimethylbutyramide derivatives and/or 1-tert-butyl-4,4-dimethyl-2,5-dioxopyrrolidine-3-carboxamides in good yields.
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-003-0619-7