Detection of cellular hypersensitivity among multiple sclerosis (MS) patients to 6/94 virus; a parainfluenza type 1 isolate from MS brain tissue

Multiple sclerosis (MS) patients and normal subjects were tested for cellular hypersensitivity, using the leukocyte migration inhibition test LMI), to a parainfluenza-1-virus (6/94), previously isolated from brain biopsy tissue of an MS patient. The response of MS patients as a group was not greater...

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Bibliographic Details
Published inInternational archives of allergy and applied immunology Vol. 48; no. 4; p. 475
Main Authors Rauch, H C, King, K M, Lewandowski, L J
Format Journal Article
LanguageEnglish
Published Switzerland 1975
Subjects
Acute Disease
Animals
Brain - microbiology
Cell Migration Inhibition
Chickens
Chronic Disease
Female
Humans
Immunity, Cellular
Leukocytes - immunology
Multiple Sclerosis - immunology
Ovum
Parainfluenza Virus 1, Human - immunology
Respirovirus - immunology
Respirovirus - isolation & purification
Virus Cultivation
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Summary:Multiple sclerosis (MS) patients and normal subjects were tested for cellular hypersensitivity, using the leukocyte migration inhibition test LMI), to a parainfluenza-1-virus (6/94), previously isolated from brain biopsy tissue of an MS patient. The response of MS patients as a group was not greater than that of normals to 6/94, but a significant increase in the response was observed among selected patients in the early active and chronic advanced stages of the disease. MS patients, however, did not differ from normal subjects in their cell response to Sendai virus, a similar parainfluenza type 1 virion used for comparison.
ISSN:0020-5915
DOI:10.1159/000231335