The role of membrane-bound ankyrin-repeat protein ACD6 in programmed cell death and plant defense

Programmed cell death (PCD) is a common defense response in plants against pathogen infection. The recently cloned ACD6 gene was identified in an Arabidopsis mutant, accelerated cell death 6 (acd6), that undergoes PCD in the absence of a pathogen challenge. ACD6 is a founding member of a large famil...

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Bibliographic Details
Published inScience's signal transduction knowledge environment (STKE) Vol. 2004; no. 221; p. pe6
Main Author Dong, Xinnian
Format Journal Article
LanguageEnglish
Published United States 24.02.2004
Subjects
Ankyrins - physiology
Apoptosis - physiology
Arabidopsis - cytology
Arabidopsis - physiology
Arabidopsis Proteins - physiology
Membrane Proteins - physiology
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Summary:Programmed cell death (PCD) is a common defense response in plants against pathogen infection. The recently cloned ACD6 gene was identified in an Arabidopsis mutant, accelerated cell death 6 (acd6), that undergoes PCD in the absence of a pathogen challenge. ACD6 is a founding member of a large family of genes that encode proteins with a short amino-terminal region, nine ankyrin repeats in the middle, and five putative transmembrane domains in the carboxyl-terminal region. Characterization of the original gain-of-function acd6 mutant and a transferred-DNA knockout mutant acd6-T showed that ACD6 is an activator of the defense pathway against bacterial pathogens and plays a role in PCD through regulation of the defense signal salicylic acid (SA). SA mediates not only downstream pathogenesis-related (PR) genes, which encode proteins with antimicrobial activities, but also ACD6, forming a feedback signal amplification loop.
ISSN:1525-8882
DOI:10.1126/stke.2212004pe6