Cellular cardiomyoplasty: a new therapeutic approach for regenerating the myocardium

One of the most promising new therapeutic techniques for the augmentation and regeneration of the myocardium is cellular cardiomyoplasty. Reports from animal and clinical investigations indicate that the transplant of different cell types, such as autologous skeletal myoblasts and adult stem cells,...

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Bibliographic Details
Published inThe Journal of cardiovascular nursing Vol. 18; no. 5; p. 374
Main Authors Piano, Mariann R, Carrigan, Timothy M
Format Journal Article
LanguageEnglish
Published United States 01.11.2003
Subjects
Animals
Cardiomyoplasty - methods
Cell Transplantation - methods
Humans
Myocardial Ischemia - pathology
Myocardial Ischemia - therapy
Myocardium - cytology
Myocardium - pathology
Myocytes, Cardiac - pathology
Myocytes, Cardiac - physiology
Myocytes, Cardiac - transplantation
Necrosis
Regeneration
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Summary:One of the most promising new therapeutic techniques for the augmentation and regeneration of the myocardium is cellular cardiomyoplasty. Reports from animal and clinical investigations indicate that the transplant of different cell types, such as autologous skeletal myoblasts and adult stem cells, into injured myocardium results in the generation of new cardiac myocytes and improvement in myocardial performance. Although there is no consensus with regard to the best cell type to transplant or the extent of myocardial renewal and regeneration, the technique of cardiac cellular myoplasty may become one of the most important advancements in the treatment of cardiovascular diseases such as myocardial infarction and heart failure.
ISSN:0889-4655
DOI:10.1097/00005082-200311000-00009